Publications by authors named "Hnin-Wint-Wint Swe"
Angiogenesis is considered essential for tumor progression; however, whether histological counting of blood vessel numbers, expressed as microvessel density (MVD), can be a prognostic factor in breast cancer remains controversial. It has been suggested that the specific morphology of blood vessels such as glomeruloid microvascular proliferation (GMP) is associated with clinical parameters. Here, we aimed to clarify the significance of MVD with revised immunohistochemistry and to identify new blood vessel shapes that predict prognosis in breast cancer.
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- - Blood vessel invasion (BVI) serves as a significant prognostic factor in various cancers, but traditional detection methods like elastic stain are not very effective for breast cancer due to false positives related to intraductal carcinoma.
- - Researchers developed a double staining technique using Victoria blue for elastin and immunohistochemistry for collagen IV, which allows for better distinction between BVI and intraductal carcinoma components.
- - The study showed that the new detection method identified BVI in 49% of breast cancer cases and correlated significantly with poor prognosis, outperforming traditional methods that showed lower rates of detection and no significant prognostic association.