Membranous nephropathy as a segmental pattern with solitary immunoglobulin A deposition: a case report.

A 67-year-old man with a history of hypertension and dyslipidemia presented with edema and heavy proteinuria. Light microscopic analysis of kidney biopsy revealed a diffuse segmental membranous feature. Immunofluorescence stain was segmentally positive for IgA, galactose-deficient IgA1, both κ and λ light chains, and C3 along the glomerular capillary walls, but negative for IgG, IgM, or C1q.

[Intraoperative Catheter Embolization for Pulmonary Artery Injury Caused by a Pulmonary Artery Catheter].

We report two cases of intraoperative transcatheter embolization for pulmonary artery injury caused by a pulmonary artery catheter( PAC). The 1st case who had severe mitral regurgitation and tricuspid regurgitation with giant left and right atrium underwent mitral and tricuspid annuloplasty. The 2nd case woman underwent aortic valve replacement and coronary artery bypass grafting.

Initial change in fractional excretion of total protein after SGLT2 inhibitors predicts renal prognosis in patients with chronic kidney disease.

Background: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) reduce glomerular hyperfiltration, resulting in an initial estimated glomerular filtration rate (eGFR) dip in chronic kidney disease (CKD). The association between the initial eGFR dip after SGLT2i and proteinuria reduction has not been explored. Fractional excretion of total protein (FETP) is an index of protein leakage corrected for GFR and may be useful in addressing this issue.

Pretreatment GFR Slopes Predict Dapagliflozin Response in IgA Nephropathy.

Introduction: Dapagliflozin exerts renoprotective effects in patients with IgA nephropathy (IgAN). However, the association between the pretreatment estimated glomerular filtration rate (eGFR) slope and posttreatment outcomes in patients with slowly progressing IgAN with optimal standard care is unclear.

Methods: This study included patients with biopsy-confirmed IgAN who were prescribed dapagliflozin during outpatient visits (August 2021-March 2022).

Slowly Progressive Secondary Adrenal Insufficiency Due to Pembrolizumab Administration in a Patient With a History of Pituitary Neuroendocrine Tumor.

A 70-year-old man developed anorexia, general malaise, and hyponatremia with a serum sodium level of 120 mEq/L after the fifth cycle of pembrolizumab administration for bladder cancer. A rapid adrenocorticotropic hormone (ACTH) loading test result was within the normal range (basal and peak cortisol levels of 8.2 μg/dL and 20.

A Case of Successful Transcatheter Coil Embolization of Multiple Systemic Arteries-to-Pulmonary Artery Fistulas.

Pulmonary vascular malformations include pulmonary arteriovenous fistula, systemic artery-to-pulmonary artery fistula (SAPAF), and systemic artery-to-pulmonary vein fistula. In particular, systemic artery-to-pulmonary artery fistulas with three or more inflow vessels are rare. Herein, we report a case of successful transcatheter coil embolization for multiple SAPAFs.

Successful Interventional Removal of a Migrated Sternal Wire in the Pulmonary Artery.

We report a case in which a migrated fractured sternal wire fragment was successfully retrieved using interventional radiology. After a median sternotomy for coronary artery bypass grafting, a migrated fracture wire initially strayed into the right ventricular myocardium, then migrated into the right pulmonary artery, and subsequently into the left pulmonary artery, 34 months after coronary artery bypass grafting. Computed tomography and angiography revealed that the wire was located in the peripheral left lower lobe branch of the A8 pulmonary artery.

Tonsillectomy in Immunoglobulin A vasculitis with nephritis: case series.

There is no consensus-based treatment for adult-onset immunoglobulin A vasculitis with nephritis (IgAV nephritis). Tonsillectomy is a treatment option for primary IgA nephropathy, which has similar histopathological features and pathogenesis to IgAV nephritis. The present case series aimed to describe the clinical course of patients with IgAV nephritis who underwent tonsillectomy in our institution.

Clinicopathological evaluation of the efficacy of endoscopic treatment for sessile serrated lesions comparing endoscopic mucosal resection, cold snare polypectomy, and underwater endoscopic mucosal resection.

Objectives: Recently, various endoscopic treatments for colorectal polyps have been reported, including cold snare polypectomy (CSP) and underwater endoscopic mucosal resection (UEMR), in addition to EMR. However, a precise treatment strategy for sessile serrated lesions (SSL) has not been established. In this study, we analyzed the clinicopathological features of SSL resected by EMR, CSP, and UEMR to determine the most suitable treatment for SSL.

Effective combination of corticosteroid and cyclosporine A for immunoglobulin A nephropathy with membranoproliferative glomerulonephritis features: a case report.

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide with heterogeneous histopathological phenotypes. Although IgAN with membranoproliferative glomerulonephritis (MPGN)-like features has been reported in children and adults, treatment strategies for this rare IgAN subtype have not been established. Here, we present the case of a 56-year-old man with no history of kidney disease who initially presented with nephrotic syndrome.

Poly(Ionic Liquid) Electrolytes at an Extreme Salt Concentration for Solid-State Batteries.

Polymer-in-salt electrolytes were introduced three decades ago as an innovative solution to the challenge of low Li-ion conductivity in solvent-free solid polymer electrolytes. Despite significant progress, the approach still faces considerable challenges, ranging from a fundamental understanding to the development of suitable polymers and salts. A critical issue is maintaining both the stability and high conductivity of molten salts within a polymer matrix, which has constrained their further exploration.

Simplified shielded MEG-MRI multimodal system with scalar-mode optically pumped magnetometers as MEG sensors.

Magnetoencephalography (MEG) conventionally operates within high-performance magnetic shields due to the extremely weak magnetic field signals from the measured objects and the narrow dynamic range of the magnetic sensors employed for detection. This limitation results in elevated equipment costs and restricted usage. Additionally, the information obtained from MEG is functional images, and to analyze from which part of the brain the signals are coming, it is necessary to capture morphological images separately.

A Man with Primary Hyperchylomicronemia with Triglyceride Levels Exceeding 11,000 mg/dL Was Well Controlled by Pemafibrate Combined with Dietary Therapy.

A 50-year-old man with a triglyceride (TG) level of 11,397 mg/dL was admitted to our hospital. He consumed a high-fat and high-carbohydrate diet as well as more than 100 g of alcohol per day. He had type 2 diabetes and obesity and had previously suffered from severe acute pancreatitis twice.

Autosomal-dominant tubulointerstitial kidney disease with a novel UMOD mutation, overlapping with Sjogren's syndrome: a case report.

Autosomal-dominant tubulointerstitial kidney disease caused by UMOD (encoding uromodulin) mutation (ADTKD-UMOD) is a rare hereditary disease. A strong family history of hyperuricemia or gout and inherited kidney disease raises the suspicion of ADTKD-UMOD. Genetic testing can confirm the diagnosis without a kidney biopsy.

Foreign Body Granuloma After Embolization of Internal Iliac Artery Aneurysm Using N-Butyl-2-Cyanoacrylate: A Case Report.

Foreign body granulomas following endovascular treatment are rare complications and are mostly reported in the brain or cutaneous vascular tissues. To the best of our knowledge, no study to date has reported on foreign body granulomas in the abdomen after injection of N-butyl-2-cyanoacrylate (NBCA)-lipiodol mixture into the abdominal arteries. This study reports a case of foreign body granuloma that appeared 12 months after the embolization of a right internal iliac artery aneurysm using an NBCA-lipiodol mixture, which posed challenges in differentiation from malignant tumors.

Acute kidney tubular injury after ingestion of red yeast rice supplement.

A 47-year-old woman developed severe kidney dysfunction after taking a lipid-lowering supplement, Red Yeast Rice Cholestehelp, for approximately 7 months. The patient developed sudden nausea and had an elevated serum creatinine level of 4.26 mg/dL.

Histological Correlation between Tonsillar and Glomerular Lesions in Patients with IgA Nephropathy Justifying Tonsillectomy: A Retrospective Cohort Study.

Tonsillectomy with steroid pulse therapy (SPT) has been established as an effective treatment for immunoglobulin A nephropathy (IgAN) in Japan. However, the underlying mechanisms supporting tonsillectomy remain unclear. This study assessed palatine tonsils from 77 patients with IgAN, including 14 and 63 who received SPT before and after tonsillectomy, respectively.

Accelerated involution of germinal center in palatine tonsils in IgA nephropathy.

Background: Altered immunological responses in the palatine tonsils may be involved in the pathogenesis of IgA nephropathy (IgAN). The germinal center serves as the site for antigen-specific humoral immune responses in the palatine tonsils. Germinal center involution is frequently observed in the palatine tonsils of IgAN (IgAN tonsils).

A 20-year follow-up study of identical twin sisters with immunoglobulin A nephropathy.

Immunoglobulin A nephropathy (IgAN) is characterized by diverse clinicopathological phenotypes. Herein we present a follow-up study of previously reported identical twin sisters with IgAN. The older sister exhibited more severe kidney histopathology and proteinuria and a lower birthweight than did her younger sister, and only the older sister experienced two childbirths.