Publications by authors named "Heloise Gauvin"
Uncovering the interaction between genomes and the environment is a principal challenge of modern genomics and preventive medicine. While theoretical models are well defined, little is known of the G × E interactions in humans. We used an integrative approach to comprehensively assess the interactions between 1.
View Article and Find Full Text PDFBackground: Founder populations have an important role in the study of genetic diseases. Access to detailed genealogical records is often one of their advantages. These genealogical data provide unique information for researchers in evolutionary and population genetics, demography and genetic epidemiology.
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- In genetics, understanding familial relationships is crucial, and recent statistical methods can effectively assess relatedness over 6-7 generations using genome-wide data.
- A study focused on the French Canadian founder population of Quebec utilized genealogical records to compare tools for identifying identity-by-descent (IBD) sharing, revealing that FastIBD correlates strongly with genealogical relationships.
- Results indicated that IBD sharing is influenced by factors like inbreeding and regional population history, highlighting that founder populations exhibit complex relatedness patterns reflected in their genetic data.
On the proportional hazards model for occupational and environmental case-control analyses.
BMC Med Res Methodol
February 2013
Background: Case-control studies are generally designed to investigate the effect of exposures on the risk of a disease. Detailed information on past exposures is collected at the time of study. However, only the cumulated value of the exposure at the index date is usually used in logistic regression.
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