A bio-guided investigation of Mitragyna inermis (Willd) O. Kuntze (Rubiaceae) unveils natural product isolates with potent cross-activity against sensitive and multidrug resistant Plasmodium falciparum strains in vitro.

Ethnobotanical Relevance: Malaria remains a significant global health challenge, especially in sub-Saharan Africa, with rising resistance to artemisinin-based therapies highlighting the urgent need for new, effective, and safer treatments from medicinal plants which have been used by the indigenous people.

Aim Of The Study: This study investigates the antiplasmodial potential of natural products from Mitragyna inermis.

Methods: Crude extracts from the stem bark and twigs of Mitragyna inermis were prepared using various solvents (water, ethanol/water, ethanol, and methanol) and tested for activity against Plasmodium falciparum strains Dd2 and 3D7 using the SYBR Green I-based fluorescence assay.

IoT based monitoring system for epileptic patients.

The unpredictable nature of epileptic seizures makes it challenging to detect and effectively treat this disorder. The seizures are random, and most epileptic patients experience dangerous physical symptoms during an attack that renders the patient uneasy when conducting their daily tasks. This paper focuses on the generalised type of epilepsy, namely "Grand mal epilepsy Tonic-Clonic (GTC) seizure.