Publications by authors named "Harrison Heath"
A comprehensive allele specific expression resource for the equine transcriptome.
BMC Genomics
January 2025
Background: Allele-specific expression (ASE) analysis provides a nuanced view of cis-regulatory mechanisms affecting gene expression.
Results: An equine ASE analysis was performed, using integrated Iso-seq and short-read RNA sequencing data from four healthy Thoroughbreds (2 mares and 2 stallions) across 9 tissues from the Functional Annotation of Animal Genomes (FAANG) project. Allele expression was quantified by haplotypes from long-read data, with 42,900 allele expression events compared.
Background: Allele-specific expression (ASE) analysis provides a nuanced view of cis-regulatory mechanisms affecting gene expression.
Results: An equine ASE analysis was performed, using integrated Iso-seq and short-read RNA sequencing data from four healthy Thoroughbreds (2 mares and 2 stallions) across 9 tissues from the Functional Annotation of Animal Genomes (FAANG) project. Allele expression was quantified by haplotypes from long-read data, with 42,900 allele expression events compared.
Article Synopsis
- Allele-specific expression (ASE) analysis helps in understanding how genes are regulated by their genetic variations.
- This study introduces a new equine ASE analysis using both long- and short-read RNA sequencing data from four Thoroughbred horses, which includes data from different tissues.
- The findings create a publicly accessible resource that can help researchers explore gene regulation in horses and better understand how genetic imbalances may affect equine health.