Publications by authors named "Harinakshi Sanikini"
Circulating hormones and risk of gastric cancer by subsite in three cohort studies.
Gastric Cancer
November 2023
Article Synopsis
- Obesity is linked to gastric cancer, with specific hormones playing a role in increasing the risk of both cardia gastric cancer (CGC) and non-cardia gastric cancer (NCGC).
- The study utilized data from multiple cohorts (EPIC, ATBC, and UK-Biobank) and assessed the relationship between obesity-related hormones and gastric cancer occurrence through various statistical methods.
- Key findings indicate that hormones like insulin-like growth-factor-1 and leptin are associated with increased risk, while ghrelin and dehydroepiandrosterone appear to have a protective effect against NCGC and CGC, respectively.
Background: Obesity has been positively associated with upper gastrointestinal cancers, but prospective data by subtype/subsite are limited. Obesity influences hormonal factors, which may play a role in these cancers. We examined anthropometry, body fat and reproductive factors in relation to oesophageal and gastric cancer by subtype/subsite in the UK Biobank cohort.
View Article and Find Full Text PDFObesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort.
View Article and Find Full Text PDFBackground: Obesity has been proposed as a potential protective factor against lung cancer. We examined the association between BMI and lung cancer risk in a pooled analysis based on nested case-control studies from four cohort studies.
Methods: A case-control study was nested within four cohorts in USA, Europe, China and Singapore that included 4172 cases and 8471 control subjects.
Prospective studies examining the association between coffee and tea consumption and gastric cancer risk have shown inconsistent results. We investigated the association between coffee (total, caffeinated and decaffeinated) and tea consumption and the risk of gastric cancer by anatomical site and histological type in the European Prospective Investigation into Cancer and Nutrition study. Coffee and tea consumption were assessed by dietary questionnaires at baseline.
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