Direct Oral Anticoagulants Compared to Warfarin in Patients with Intermediate- to High-Risk Pulmonary Embolism: A Systematic Review and Meta-Analysis.

Introduction: Despite recent advances in clinical therapeutics in patients with venous thromboembolism, uncertainty remains regarding the optimal anticoagulation strategy in patients with intermediate- to high-risk pulmonary embolism. We aimed to evaluate the direct oral anticoagulants' effectiveness and safety compared to warfarin in patients with intermediate- and high-risk pulmonary embolism.

Methods: In this meta-analysis, we systematically searched databases PubMed, EMBASE, Web of Science, and the Cochrane Library from their inception to April 30, 2024, for eligible studies that satisfy inclusion criteria.