Publications by authors named "Haein Yu"
Spatiotemporal distributions of total and methylmercury in bivalves from coastal zones of South Korea.
Mar Pollut Bull
November 2025
We measured the concentrations of total mercury (THg) and methylmercury (MeHg) in bivalves (mussels and oysters) collected from 46 sites in coastal zones of Korea in 2019 and 2020. THg and MeHg concentrations in bivalves ranged from 1.6 to 41.
View Article and Find Full Text PDFHere we systematically investigated genomic alterations from the initiation of induced pluripotent stem (iPS) cell generation to induced mesenchymal stromal/stem cell differentiation. We observed a total of ten copy number alterations (CNAs) and five single-nucleotide variations (SNVs) during the phases of reprogramming, differentiation and passaging. We identified a higher frequency of CNAs and SNVs in iPS cells generated using the Sendai virus (SV) method compared with those generated with episomal vectors (Epi).
View Article and Find Full Text PDFAnalytical performance of the Abbott ID NOW 2.0 assay for SARS-CoV-2 detection in clinical samples from symptomatic patients.
Diagn Microbiol Infect Dis
March 2024
We evaluated the analytical performance of ID NOW™ COVID-19 2.0 assay versus conventional real-time reverse transcription-polymerase chain reaction (RT-PCR) using a total of 792 clinical samples from nasopharyngeal and oropharyngeal swabs, stored in frozen universal transport medium samples. Positive percent agreement (PPA) and negative percent agreement of ID NOW were 97.
View Article and Find Full Text PDFArticle Synopsis
- Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries but is rare in Asia, leading to limited genetic studies in this region.
- This research focused on genetically analyzing 113 CLL patients from Korea using next-generation sequencing, discovering that mutations such as L265P and V217F were prevalent.
- The study found that patients with certain genetic conditions, like somatic hypermutation (SHM) and specific mutations, had better treatment outcomes and overall survival compared to those without these features.
Article Synopsis
- Juvenile myelomonocytic leukaemia (JMML) is a rare childhood blood disorder that presents challenges in diagnosis due to its varied symptoms and clinical progression.
- A study analyzed 24 JMML patients, revealing that 88% had RAS pathway mutations, with common genes affected including PTPN11 and NRAS.
- The overall 5-year event-free survival rate was around 58.9%, with NRAS positive patients showing better survival outcomes compared to other genetic profiles.
Article Synopsis
- HLA identification at the allelic level is crucial for stem cell transplantation, and next-generation sequencing (NGS) is effective in resolving ambiguous alleles.
- The study evaluated the performance of NGS for HLA-SBT by analyzing data from 1,293 healthy donors, covering key HLA loci and including quality control measures.
- Results showed high concordance (99.7%) between SBT-HLA and NGS-HLA typing, with NGS successfully resolving ambiguous and previously unassigned alleles, highlighting its potential for clinical use in HSCT.
Background: It is very important to accurately enumerate CD34-positive (CD34+) cells for successful hematopoietic stem cell transplantation (HSCT). We evaluated the ability of the newly developed image based-immunofluorescence cell counter ADAMII (NanoEntek, Seoul, Korea) to enumerate CD34+ cells, which was improved through simultaneous CD45 analysis.
Methods: We enumerated CD34+ cells with ADAMII using 19 peripheral blood (PB) and 91 leukapheresis samples from HSCT donors.
Determination of posaconazole concentration with LC-MS/MS in adult patients with hematologic malignancy.
Clin Chim Acta
October 2015
Article Synopsis
- Posaconazole is an antifungal medication that helps prevent invasive fungal infections (IFIs) but has inconsistent effectiveness due to variable absorption from its oral suspension formulation.
- A study involving 122 adult patients receiving chemotherapy for AML/MDS measured posaconazole concentrations at various points, finding that lower concentrations were linked to a higher occurrence of IFIs.
- The results suggest that therapeutic drug monitoring (TDM) of posaconazole is important, with specific dosages associated with better outcomes, and factors like food intake can significantly influence drug levels.