Publications by authors named "Hadhud Mohamad"
Background: Real-world data demonstrate variability in the response to elexacaftor/tezacaftor/ivacaftor (ETI) treatment among people with CF (pwCF). The aim of this study was to evaluate long-term outcomes in pwCF that had not shown early improvement in the percentage of predicted FEV (ppFEV) following ETI treatment.
Methods: A single-center prospective study in pwCF who initiated ETI.
Lung cancer is uncommon among people with cystic fibrosis (pwCF). We describe the case of a 35-year-old man with mild, stable CF disease who presented with severe respiratory distress, systemic symptoms, elevated liver enzymes and hypereosinophilia along with a lung mass and pleural effusion. The patient was subsequently diagnosed with non-small cell lung carcinoma (NSCLC), featuring anaplastic lymphoma kinase (ALK) translocation.
View Article and Find Full Text PDFRisk Factors for Developing Adenovirus-Associated Post-Infectious Bronchiolitis Obliterans.
Pediatr Pulmonol
January 2025
Background: Risk factors for progression of adenovirus (AdV)-associated bronchiolitis (AdV-B) to post-infectious bronchiolitis obliterans (PIBO) are poorly defined. We aimed to investigate this in a multicenter cohort.
Methods: A multicenter hospital-based analysis included children admitted with AdV-B in Jerusalem during 2016-2022.
Article Synopsis
- Next-generation sequencing and data exchange platforms have greatly improved molecular diagnoses for families by using a semi-automated genematching algorithm focused on genotype and phenotype matching.
- The study involved analyzing rare homozygous variants from a database of about 12,000 exomes and calculating phenotype similarity scores to identify correlations between affected individuals.
- The approach successfully identified 33,792 genotype-matched pairs across unique genes, highlighting the effectiveness of this method in isolating candidates for disease-related genes and improving the understanding of variants of uncertain significance.
Article Synopsis
- Adjusting the chronological age of preterm infants based on their gestational age is common in neurodevelopment, particularly when assessing for serious bacterial infections (SBI).
- A study analyzed 448 preterm infants who presented to pediatric emergency departments, revealing that those with a corrected age below 3 months had a significantly higher incidence of SBI compared to those with corrected ages above 3 months.
- The findings suggest that preterm infants with corrected ages under 3 months are at similar risk for SBI as term infants under 3 months, highlighting the need for age correction when evaluating febrile preterm infants.
Background: Although hematopoietic stem cell transplantation (HSCT) is the only curative option for some children with malignant and nonmalignant disorders, the procedure itself carries a high risk of complications. A proportion of children undergoing HSCT develop severe transplant-related complications requiring hospitalization in the pediatric intensive care unit (PICU).
Methods: A retrospective cohort study included 793 children with malignant and nonmalignant diseases that underwent 963 HSCTs in two large pediatric hospitals over 15 years.