Publications by authors named "Gyo Inoue"
The relationships of human diversity with biomedical phenotypes are pervasive yet remain understudied, particularly in a single-cell genomics context. Here, we present the Asian Immune Diversity Atlas (AIDA), a multi-national single-cell RNA sequencing (scRNA-seq) healthy reference atlas of human immune cells. AIDA comprises 1,265,624 circulating immune cells from 619 donors, spanning 7 population groups across 5 Asian countries, and 6 controls.
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- Researchers used a 5' single-cell RNA sequencing method to identify where enhancer RNAs and other RNA types start in human CD4 T cells, uncovering variations in cell types and their development.
- By combining these RNA datasets with single-cell chromatin profiles, they found that unique active enhancers and their RNA production are specific to certain cell types and are linked to disease risk.
- The study created a detailed atlas of these enhancers that helps to understand how genetic variations are related to various immune-mediated diseases.
Collismycin A (CMA), a microbial product, has anti-proliferative activity against cancer cells, but the mechanism of its action remains unknown. Here, we report the identification of the molecular target of CMA by ChemProteoBase, a proteome-based approach for drug target identification. ChemProteoBase profiling showed that CMA is closely clustered with di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone, an iron chelator.
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