A new lectin from mushroom with potent anti-inflammatory activity.

This study used 80% ammonium sulphate fractional precipitation, followed by affinity chromatography to purify a new lectin (AVL) from the crude extract of the mushroom. The purification procedure achieved a 20% yield, a specific activity of 5120 HU/mg protein, and a 16-fold increase in purity. SDS-PAGE analysis showed a single band of 45 kDa.

and mutations as drivers of paclitaxel resistance in breast cancer cells.

Breast cancer (BC) is the most prevalent cancer type in the world, with increasing incidence rates. Drug resistance is a notable factor that limits the effectiveness of BC therapy. Paclitaxel (PTX), a chemotherapeutic agent belonging to the taxane class, is commonly used in BC; however, its efficacy is often compromised by drug resistance, which is primarily attributed to genetic alterations.

Sesquiterpene Coumarins, Chromones, and Acetophenone Derivatives with Selective Cytotoxicities from the Roots of M. Bieb. (Apiaceae).

In search of selective cytotoxic compounds from species as potential leads for the treatment of various cancer diseases, a bioactivity-guided isolation study was performed on the roots of M. Bieb. COLO 205 (colon), K-562 (leukemia), and MCF-7 (breast) cancer cell lines were used to monitor the cytotoxic activity of column fractions and determine the IC value of the active compounds.

Sesquiterpene Coumarin Ethers with Selective Cytotoxic Activities from the Roots of Peşmen (Apiaceae) and Unequivocal Determination of the Absolute Stereochemistry of Samarcandin.

Ancient physicians frequently used the resin of species to treat cancer. Today, some folkloric recipes used for cancer treatment also contain the resin of species. The dichloromethane extract of the roots of exhibited cytotoxic activities against COLO 205 (colon), K-562 (lymphoblast), and MCF-7 (breast) cancer cell lines (IC = 52 µg/mL, 72 µg/mL, and 20 µg/mL, respectively).

Novel Cytotoxic Sesquiterpene Ester Derivatives from the Roots of Ferula mervynii.

This study is the first chemical investigation of Ferula mervynii M. Sağıroğlu & H. Duman, an endemic species to Eastern Anatolia.

Identification of /β-catenin mutations conferring cetuximab and chemotherapeutic drug resistance in colorectal cancer treatment.

In anticancer therapy, the effectiveness of therapeutics is limited by mutations causing drug resistance. mutations are the only determinant for cetuximab resistance in patients with colorectal cancer (CRC). However, cetuximab treatment has not been fully successful in the majority of patients with wild-type (WT) .