Development and characterization of dual drug loaded magnetic gold nanohybrid system for osteoarthritis.

Cartilage deterioration in patients with osteoarthritis presents a significant challenge, primarily attributable to the inadequate oral bioavailability and poor dosage compliance of chondroprotective agents. The Chondroitin Sulphate (CS) is a stabilizing and reducing agent for metal NP as well as homing agent by binding to surface molecules (CD44, L-selectin, P-selectin, and annexin-6) of chondrocytes at the OA site. This study was designed to develop intra-articular magnetic gold nanohybrids for the co-delivery of chondroitin sulfate, glucosamine sulfate, and gold, aiming to achieve synergistic anti-inflammatory and cartilage regenerative effects and in vitro assessments of drug release were conducted.

Assessment of the potential and application of BeO nanocage for removal of ciprofloxacin from water employing density functional theory.

The modern world is facing the issue of emerging pollutants for its sustainable development. We report a detailed study on the abatement of ciprofloxacin (CIP) by BeO nanocage. Five different geometries of BeO nanocage with CIP i.

Hormesis management of with exogenous application of plant growth regulators under saline conditions.

The study investigated the adaptability of to saline conditions, focusing on its hormesis behavior. It also examined how various plant growth regulators affected growth, physiological parameters, and bioactive compounds of moringa. In the first phase, different NaCl stress levels (0, 50, 100, 150, 200, and 250 mM) were applied.

Evaluation of Entomopathogenic Nematodes against Red Palm Weevil, (Olivier) (Coleoptera: Curculionidae).

Entomopathogenic nematodes play a pivotal role as biocontrol agents for different species of insect pests, including the red palm weevil. In the current investigation, the infective capabilities of four species of entomopathogenic nematodes, including , , , and , were evaluated against larvae, pupae, and adult red palm weevil under laboratory and field conditions. The pathogenic potential of selected nematode species was assessed based on dissection and adult emergence of weevils.

Metalliferous conditions induce regulation in antioxidant activities, polyphenolics and nutritional quality of L.

L. was grown under cadmium and lead stress conditions and the variations in its mineral content, polyphenolics, and antioxidant activities were studied and how these heavy metals affect plant growth and development. In this study, the metal translocation factor was found <1 which indicates more metal accumulation in moringa roots than stem.

Electronic structure, optical and photocatalytic performance of SiC-MX (M = Mo, W and X = S, Se) van der Waals heterostructures.

The stacking of monolayers in the form of van der Waals heterostructures is a useful strategy for band gap engineering and the control of dynamics of excitons for potential nano-electronic devices. We performed first-principles calculations to investigate the structural, electronic, optical and photocatalytic properties of the SiC-MX (M = Mo, W and X = S, Se) van der Waals heterostructures. The stability of most favorable stacking is confirmed by calculating the binding energy and phonon spectrum.

Randomized controlled trial of standard versus double dose cotrimoxazole for childhood pneumonia in Pakistan.

Objective: Increasing concern over bacterial resistance to cotrimoxazole, which is recommended by WHO as a first-line drug for treating non-severe pneumonia, led to the suggestion that this might not be optimal therapy. However, changing to alternative antimicrobial agents, such as amoxicillin, is costly. We compared the clinical efficacy of twice-daily cotrimoxazole in standard versus double dosage for treating non-severe pneumonia in children.