Publications by authors named "Guining Fu"
Prospective study of Tc-3PRGD SPECT/CT diagnosing metastatic lymph nodes in esophageal squamous cell carcinoma.
Thorac Cancer
September 2024
Background: Lymph node (LN) metastasis is a significant prognostic factor for esophageal squamous cell carcinoma (ESCC), and there are no satisfactory methods for accurately predicting metastatic LNs. The present study aimed to assess the efficacy of Tc-3PRGD single-photon emission computed tomography (SPECT)/computed tomography (CT) for diagnosing metastatic LNs in ESCC.
Methods: A total of 15 enrolled patients with ESCC underwent Tc-3PRGD SPECT/CT and 18F-fluorodeoxyglucose positron emission tomography-computed tomography (F-FDG PET/CT) examinations preoperatively.
Article Synopsis
- Lung adenocarcinoma (LUAD) is a major cause of cancer deaths, and understanding DNA methylation in early stages could help improve treatment outcomes.
- Researchers used enzymatic methyl sequencing to analyze 23 tumor samples alongside normal tissues, revealing a more detailed epigenetic landscape than previous methods.
- The study identified over 30,000 differentially methylated regions and developed a prognostic model based on six significant genes, offering new insights into the role of DNA methylation in early-stage LUAD.