RISK STRATIFICATION PROTOCOL FOR PERFORMING TOTAL KNEE ARTHROPLASTY.

Objective: the main objective of the study was to evaluate a screening protocol for performing total knee arthroplasty (TKA) without postoperative admission to an intensive care unit (ICU). The secondary objective was to evaluate the postoperative blood transfusion rate.

Method: between January 2020 and December 2021, 270 TKA were performed, following a clinical protocol: age up to 75 years, body mass index up to 35 kg/m2, ASA score classification I or II, non-smoker, without history of ischemic disease (coronary or cerebral), creatinine clearance greater than 60 mL/min, hemoglobin greater than 12 g/dL and osteoarthritis with deformity treatable with primary prosthesis (fixed or rotating base).

Genetic Modifiers of HbF in HbAA and HbAS Women From São Tomé e Príncipe: An Association Study of Common Genetic Variants in , , , and .

Background: While an increase in fetal hemoglobin (HbF) has no consequences in healthy adults, clinical benefits can be promoted in sickle cell disease (SCD) and β-thalassemia patients. Single-nucleotide polymorphisms (SNPs) in three genomic regions: the gene cluster, the gene, and the () intergenic region, have been associated with HbF regulation. Therefore, the present study aimed to examine the potential association of SNPs in (rs11886868 and rs1427407), (rs66650371 and rs4895441), (rs7482144), and (rs7924684) with HbF levels in an adult population sample from São Tomé e Príncipe (Central Africa).

Infection in Wild Trahira () and Farmed Arapaima () in Brazil: An Interspecies Transmission in Aquatic Environments Shared with Nile Tilapia ().

is an important pathogen responsible for cases of high mortality in farmed and wild fish worldwide. In Brazil, this bacterium has been commonly associated with outbreaks in Nile tilapia farms, but other native fish species are also susceptible. Since floating cages are one of the most common culture systems used in the country, the close contact between farmed tilapia and native fish species presents a risk concerning the transmission of this pathogen.

Occupational accidents among workers within a microarea covered by the Family Health Strategy.

Introduction: Occupational accidents are events that tend to be highly underreported in Brazil's official reporting systems. In this context, surveys with primary data collection are important to provide a better dimensioning of these events.

Objectives: To characterize workers who had a non-fatal occupational accident within the microarea of a Family Health Unit in Salvador, state of Bahia, Brazil.

Duration of Protection and Humoral Immune Response in Nile Tilapia ( L.) Vaccinated against .

Streptococcosis caused by ( is a major bacterial disease affecting the production of Nile tilapia ( L.), causing significant economic losses due to mortality in the growing phase. Vaccination is the most effective method for preventing streptococcosis on Nile tilapia farms.

Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age.

Background: Sickle Cell Disorder is Africa's most prevalent genetic disease. Yet, it remains a neglected condition, with high mortality under-five, and a lack of population-based studies in the region. This is the first of its kind in São Tomé e Príncipe, aiming to estimate the prevalence of sickle cell trait and other haemoglobin variants in women of reproductive age and its associated factors.

Experimental Infection and the Effects of Temperature on the Pathogenicity of the Infectious Spleen and Kidney Necrosis Virus in Juvenile Nile Tilapia ().

The infectious spleen and kidney necrosis virus (ISKNV) is one of the most important emerging viral pathogens for Nile tilapia () farming. While prevalent worldwide, it has recently been detected in Brazil. However, despite the importance of the virus and the affected fish species, there are no scientific data on the effects of water temperature on disease pathogenesis in Nile tilapia.

Assessment of the Implementation of the International Health Regulations during the COVID-19 Pandemic: Portugal as a Case Study.

Introduction: The International Health Regulations (IHR) were developed to prepare countries to deal with public health emergencies. The spread of SARS-CoV-2 underlined the need for international coordination, although few attempts were made to evaluate the integrated implementation of the IHR's core capacities in response to the COVID-19 pandemic. The aim of this study was to evaluate whether IHR shortcomings stem from non-compliance or regulatory issues, using Portugal as a European case study due to its size, organization, and previous discrepancies between self-reporting and peer assessment of the IHR's core capacities.

Prepandemic psychotropic drug status in Portugal: a nationwide pharmacoepidemiological profile.

The prescription of psychotropic drugs has been rising in Europe over the last decade. This study provides a comprehensive profile of prepandemic consumption patterns of antidepressant, antipsychotic, and anxiolytic drugs in Portugal considering full nationwide psychotropic drug prescription and dispensing records (2016-2019) against several criteria, including active ingredient, sociodemographics, medical specialty, and incurred costs. An increase of 29.

Therapeutic efficacy of enrofloxacin in treatment of Francisella orientalis infections in juvenile Nile tilapia (Oreochromis niloticus L.).

Outbreaks of infections by Francisella orientalis represent one of the main obstacles to Nile tilapia (Oreochromis niloticus L.) farming. It is responsible for acute mortality in fingerlings and juveniles.

Artificial cornea transplantation and visual rehabilitation: an integrative review.

Due to the development of complications and the biocompatibility and scarcity of transplant donor tissues, artificial corneas, which can be used for the rehabilitation of optical functions, have been developed. The current study aimed to analyze the visual rehabilitation effects of the Boston type I keratoprosthesis, Boston type II keratoprosthesis, Aurolab keratoprosthesis, osteo-odonto-keratoprosthesis, and tibial bone keratoprosthesis. Results showed that the Boston type I keratoprosthesis was the most effective for visual rehabilitation in patients with moist ocular surfaces.

Cordon sanitaire, a necessary evil? Evaluation of non-pharmacological interventions against COVID-19 in Ovar, Portugal.

Background And Aim: From March 17 to April 17, 2020, the Portuguese municipality of Ovar was submitted to a cordon sanitaire due to a COVID-19 outbreak. During this period a whole Public Health structure had to be built up to respond to the healthcare needs of the population. The aim of this work is to contribute to the evidence on the efficacy of cordon sanitaire as an epidemic control strategy.

COVID-19 and Its Symptoms' Panoply: A Case-Control Study of 919 Suspected Cases in Locked-Down Ovar, Portugal.

Background: Ovar was the first Portuguese municipality to declare active community transmission of SARS-CoV-2, with total lockdown decreed on March 17, 2020. This context provided conditions for a large-scale testing strategy, allowing a referral system considering other symptoms besides the ones that were part of the case definition (fever, cough, and dyspnea). This study aims to identify other symptoms associated with COVID-19 since it may clarify the pre-test probability of the occurrence of the disease.

Self and world experience in non-affective first episode of psychosis.

A disturbance of "minimal self," - of the immediate sense of mine-ness inherent in experience-is hypothesized to be the core disturbance in schizophrenia. Research with the Examination of Anomalous Self Experience (EASE) has demonstrated the selective aggregation of anomalous self-experiences in the schizophrenia spectrum. Conceptual research suggests that anomalous world experiences, including changes in the experience of space, time, and other persons, occur alongside anomalous self-experiences and are an important aspect of subjectivity in schizophrenia.

Streptococcus agalactiae Sequence Type 283 in Farmed Fish, Brazil.

In 2016 and 2017, we characterized outbreaks caused by Streptococcus agalactiae serotype III sequence type (ST) 283 in Nile tilapia farms in Brazil. Whole-genome multilocus sequence typing clustered the fish isolates together with the zoonotic ST283 and other STs related to cases in humans, frogs, dogs, cattle, and dolphins.

[Pathogenic bacteria dissemination by ants (Hymenoptera: Formicidae) in two hospitals in northeast Brazil].

Nosocomial infections bring a high risk to the health of hospital patients and employees. Ants are common organisms in Brazilian hospitals, where they can act as dispersers of opportunistic microorganisms in places they forage. The occurrence of multi-resistant bacteria carried by ants was analyzed in two public hospitals (HA and HB) in southeastern Bahia, Brazil.