Electrochemical oxygen activation driven by enamine-keto push-pull interactions in triazole-based covalent organic polymers.

We have developed two triazole-based covalent organic polymers (COPs) with donor-acceptor motifs. The keto-enriched COP demonstrated exceptional oxygen activation electrochemical stimuli, driven by strong push-pull interactions. studies and DFT calculations confirmed the critical role of enamine carbon positive charges in enhancing performance, setting new benchmarks in COP design.

Hybrids of Benzimidazole-oxadiazole: A New Avenue for Synthesis, Pharmacological Activity and Recent Patents for the Development of More Effective Ligands.

Background: Two significant families of compounds i.e. 1,3,4-oxadiazole and benzimidazole, have undergone extensive investigation into their pharmacological characteristics and possible therapeutic applications.

Pd "Kills Two Birds with One Stone" for the Synthesis of Catalyst: Dual Active Sites of Pd Triggers the Kinetics of O Electrocatalysis.

Noble metal-based catalyst, despite their exorbitant cost, are the only successful catalyst for bifunctional oxygen electrocatalysis owing to their capability to drive forward the reaction rate kinetically. Therefore, it is desirable to diminish the noble metal loading without any compromise in the catalyst performance. In this study, the aim to achieve two goals with one action via a single-step route to have ultra-low loading of Pd in the catalyst.

Coordination Engineering of Dual Co, Ni Active Sites in N-Doped Carbon Fostering Reversible Oxygen Electrocatalysis.

The development of affordable and non-noble-metal-based reversible oxygen electrocatalysts is required for renewable energy conversion and storage systems like metal-air batteries (MABs). However, the nonbifunctionality of most of the catalysts impedes their use in rechargeable MAB applications. Moreover, the loss of active sites also affects the long-term performance of the electrocatalyst toward oxygen electrocatalysis.

1,3,4-Oxadiazoles as Anticancer Agents: A Review.

Among the deadliest diseases, cancer is characterized by tumors or an increased number of a specific type of cell because of uncontrolled divisions during mitosis. Researchers in the current era concentrated on the development of highly selective anticancer medications due to the substantial toxicities of conventional cytotoxic drugs. Several marketed drug molecules have provided resistance against cancer through interaction with certain targets/growth factors/enzymes, such as Telomerase, Histone Deacetylase (HDAC), Methionine Aminopeptidase (MetAP II), Thymidylate Synthase (TS), Glycogen Synthase Kinase-3 (GSK), Epidermal Growth Factor (EGF), Vascular Endothelial Growth Factor (VEGF), Focal Adhesion Kinase (FAK), STAT3, Thymidine phosphorylase, and Alkaline phosphatase.

Synthetic approaches and applications of an underprivileged 1,2,5-oxadiazole moiety: A review.

1,2,5-oxadiazole belongs to five-membered heterocyclic compounds with two nitrogen and one oxygen atom. In comparison with other heterocyclic moieties, 1,2,5-oxadiazoles moiety is considered as underprivileged as it attracted little attention of the researchers although lot of scopes and possible applications in medicinal, material and agriculture science. 1,2,5-oxadiazole and its derivatives have been reported as good pharmacophores as carbonic anhydrase inhibitors, antibacterial, vasodilating agents, antimalarial, anticancer, etc.

Dual active sites in a triazine-based covalent organic polymeric framework promoting oxygen reduction reaction.

A new significant feature of a triazine-based covalent organic polymer electrocatalyst is demonstrated. The metal-free electrocatalyst has dual-active sites, which enable it to entangle oxygen a push-pull interaction that plays a crucial role in promoting the oxygen reduction reaction.