Dual Benefits of Oral Tranexamic Acid: Reducing Melasma Severity and Inflammation.

Background: Melasma is a chronic hyperpigmentation disorder influenced by hormonal factors, ultraviolet exposure, and inflammation. While oral tranexamic acid (TXA) is an established treatment, its effects on systemic inflammation remain unclear.

Aims: This study aimed to evaluate the impact of TXA on melasma severity and inflammatory markers.

Efficacy, safety, and recurrence in seborrheic dermatitis: A dose-dependent analysis of oral isotretinoin (10 mg vs 20 mg).

Background: This study aimed to compare the efficacy, recurrence rates, and patient-reported satisfaction of 10 mg versus 20 mg daily isotretinoin in individuals with moderate to severe seborrheic dermatitis.

Methods: A retrospective cohort study was conducted on 234 patients treated with 10 mg (n = 126) and 20 mg (n = 108) isotretinoin. Disease severity was assessed using the Seborrheic Dermatitis Area Severity Index (SDASI), while quality of life and treatment satisfaction were evaluated using the Dermatology Life Quality Index (DLQI) and Treatment Satisfaction Questionnaire for Medication 9.

Unveiling the effectiveness and safety spectrum of biologic therapies in psoriasis: a three-year real-world analysis.

Background: Psoriasis vulgaris is a chronic immune-mediated inflammatory disease that significantly affects quality of life, particularly in severe cases and anatomically challenging areas. Biologic therapies targeting immune pathways have improved clinical outcomes; however, variability in effectiveness, safety, and drug survival necessitates further investigation.

Objectives: This study aimed to evaluate the effectiveness, safety, and drug survival of biologic therapies in patients with moderate-to-severe psoriasis vulgaris.

Self-Induced Nail Disorders: Clinical and Demographical Features.

Background: Self-induced nail disorders (SINDs) are a subset of body-focused repetitive behaviors (BFRBs) characterized by pathological grooming habits that damage the nail and periungual structures. These disorders were classified into subgroups based on the specific methods individuals use to harm their nails. Despite their prevalence and potential psychological impact, limited data exist.

Systemic Anti-Inflammatory Effects of Isotretinoin: Evaluation of Red Cell Distribution Width to Lymphocyte and Platelet Ratios as New Hematological Markers and Clinical Outcomes in Acne Vulgaris.

Background: Acne vulgaris is a chronic inflammatory skin disease influenced by systemic immune responses. While isotretinoin is the most effective treatment for severe acne, its effects on hematological markers of inflammation, in particular red cell distribution width (RDW)-to-lymphocyte and RDW-to-platelet ratios, remain unclear.

Methods: This retrospective study analyzed 450 acne patients treated with isotretinoin for at least 24 weeks.

Vascular Remodeling in Rosacea: A Study on Microcirculatory Insights Using Oral Capillaroscopy.

Background: Rosacea is a chronic inflammatory skin condition characterized by facial erythema, telangiectasia, and papules. Although clinical assessment is essential for diagnosis, objective criteria for evaluating severity are lacking. This study aimed to investigate the relationship between rosacea severity, disease duration, and associated microvascular changes through oral mucosal capillaroscopy.

The relationship between hidradenitis suppurativa and irritable bowel syndrome: a cross-sectional study.

Background: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder in which one experiences abdominal pain, tension, cramping, bloating, and changes in the form and frequency of defecation, without an underlying organic disease. Many skin diseases have been reported to be more common in people with functional bowel disease. To our knowledge, however, no previous study investigated the potential relationship between hidradenitis suppurativa (HS) and IBS.

Potential Utility of Oral Mucosal Capillaroscopy as an Indicator of Microvascular Damage in Behçet Disease: A Preliminary Study.

Introduction: Behçet disease (BD) is an auto-inflammatory condition characterized by multisystemic vasculitis. Oral mucosal capillaroscopy is an easy-to-use, repeatable, non-invasive method for evaluating mucosal microvasculature, contributing to the differential diagnosis and prognosis of various acute and chronic inflammatory diseases.

Objectives: This study aims to characterize and describe the oral labial mucosal capillary findings in patients with BD using handheld dermatoscopy and to investigate the relationship between the capillary findings and the severity of the disease.

Relationship between rosacea and chronic obstructive pulmonary disease: Rosacea and comorbidities: Rosacea and comorbidities.

Background: Rosacea is a chronic inflammatory skin disease that has been reported to be associated with many systemic disorders including respiratory diseases.

Aims: This study aims to investigate respiratory function in patients with rosacea.

Patients/methods: Patients with rosacea and age- and gender-matched healthy volunteers were included in this cross-sectional study.

The role of cystatin-C and fetuin-A in the determination of early atherosclerotic risk in psoriasis patients.

Psoriasis is associated with an increased risk of atherosclerosis. The objective of this study is evaluate the relationship between carotid intima-media thickness (CIMT) serum and cystatin-C, fetuin-A levels in determining the increased risk of subclinical atherosclerosis in psoriasis patients. In this study, age and gender compatible 80 psoriasis patients and 78 healthy individuals were included.

The effects of isotretinoin therapy on the biliary system.

The aim of the present study was to investigate the potential effects of isotretinoin on the biliary system in patients with acne vulgaris receiving isotretinoin therapy. This was a preliminary retrospective study involving 40 patients with severe acne vulgaris who attended the dermatology clinic and were administered different doses (20 or 30 mg/day) of isotretinoin. Serum levels of AST, ALT, ALP, GGT, total bilirubin, direct bilirubin, and indirect bilirubin at the beginning and at the first month of therapy were scanned, recorded, and statistically analyzed.