Publications by authors named "Gopalakrishnan Ravikumar"
Article Synopsis
- - Sjogren's syndrome (SS) is an autoimmune disease mainly affecting women, targeting glands like salivary and lacrimal glands, leading to symptoms such as dry mouth (xerostomia) and dry eyes (keratoconjunctivitis).
- - In adults, the most common kidney issue associated with SS is tubulointerstitial nephritis, often presenting as renal tubular acidosis (RTA), while this condition is less common in children, occurring in only 7.1-19.2% of cases.
- - The text describes a specific case of SS in a patient that resulted in hypokalemic paralysis due to an underlying condition of distal renal tubular acidosis (dRTA).
Article Synopsis
- * Transcranial Doppler (TCD) screening has notably reduced pediatric stroke incidence, but there's still a gap in understanding optimal hydroxyurea dosing and the identification of silent cerebral strokes in adults.
- * Adult stroke prevention in sickle cell patients is under-researched, and more studies are needed to address the prevalence of silent infarctions and other neurological issues linked to the disease.
Monkeypox virus (MPOX) is a zoonotic disease in humans. It is similar genetically to its virus family member, smallpox. This virus has been studied since the 1970s.
View Article and Find Full Text PDFLeptospirosis is a bacterial zoonotic disease that causes abortions, infertility and mastitis in cattle. This research was aimed at investigating the temporal and spatial pattern, sex, age, breed wise distribution of leptospirosis in Tamil Nadu. A seroreactivity of 28.
View Article and Find Full Text PDFis one of the aetiological trematodes associated with fascioliasis, which heavily impacts food-production systems and human and animal welfare on a global scale. In the absence of a vaccine, fascioliasis control and treatment is restricted to pasture management, such as clean grazing, and a limited array of chemotherapies, to which signs of resistance are beginning to appear. Research into novel control strategies is therefore urgently required and the advent of 'omics technologies presents considerable opportunity for novel drug and vaccine target discovery.
View Article and Find Full Text PDFThe liver flukes Fasciola hepatica and F. gigantica infect livestock worldwide and threaten food security with climate change and problematic control measures spreading disease. Fascioliasis is also a foodborne disease with up to 17 million humans infected.
View Article and Find Full Text PDFRNAi dynamics in Juvenile Fasciola spp. Liver flukes reveals the persistence of gene silencing in vitro.
PLoS Negl Trop Dis
September 2014
Background: Fasciola spp. liver fluke cause pernicious disease in humans and animals. Whilst current control is unsustainable due to anthelmintic resistance, gene silencing (RNA interference, RNAi) has the potential to contribute to functional validation of new therapeutic targets.
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