Study protocol for a prospective natural history registry investigating the relationships between inflammatory markers and disease progression in retinitis pigmentosa: the RP-PRIMARY study.

Purpose: The Retinitis Pigmentosa Progression and Inflammatory Marker Registry (RP-PRIMARY) is intended as a prospective observational study aimed at establishing sensitive outcome measures to detect the efficacy of anti-inflammatory agents in future clinical trials. The following is the RP-PRIMARY study protocol.

Study Design: Prospective, multicenter study.

Efficacy of a wearable night-vision aid in patients with concentric peripheral visual field loss: a randomized, crossover trial.

Purpose: To investigate the efficacy of our wearable night-vision aid in patients with concentric peripheral visual field loss.

Study Design: Prospective, single blind, three-group, and three-period crossover clinical study.

Methods: The study included patients with concentric peripheral visual field loss, a best-corrected visual acuity (decimal visual acuity) of 0.

CLEC3B is a novel causative gene for macular-retinal dystrophy.

Purpose: Macular degeneration is the leading cause of blindness worldwide. In this study, we aimed to define a new subtype of macular-retinal dystrophy and its genetic predisposition in 5 families.

Methods: Exome sequencing was performed to determine the putative disease-causing genes in patients with inherited macular disorders confirmed through comprehensive ophthalmic examinations.

Genetic and Phenotypic Landscape of -Associated Retinal Dystrophy in Japan.

() is one of the causative genes of inherited retinal dystrophy. While the gene is relatively common in Caucasians, reports from Asian ethnicities are limited. In the present study, we report 40 Japanese patients from 30 families with -associated retinal dystrophy.

Base Curve of Progressive Addition Lenses Influences Clear Vision and Stereopsis Area.

Purpose: Progressive addition lenses (PAL) are effective, particularly for middle-aged and elderly people who require reading spectacles. However, with PALs, peripheral vision may be distorted and blurred because of both the lateral bending of the surface and the effect of unequal bending of the light coming from an off-axis location in the tangential and sagittal directions, which may lead to a decrease in the quality of vision. Till date, no evaluation of PALs has been reported with regard to peripheral and binocular vision.

Correction to: Clinical and genetic characteristics of 14 patients from 13 Japanese families with -associated retinal disorder: report of eight novel variants.

[This corrects the article DOI: 10.1038/s41439-019-0065-7.].

Clinical and genetic characteristics of 14 patients from 13 Japanese families with -associated retinal disorder: report of eight novel variants.

Variants in the retinitis pigmentosa GTPase regulator (RPGR) gene are a major cause of X-linked inherited retinal disorder (IRD). We herein describe the clinical and genetic features of 14 patients from 13 Japanese families harboring variants in a nationwide cohort. Comprehensive ophthalmological examinations were performed to classify the patients into one of the phenotype subgroups: retinitis pigmentosa (RP) and cone rod dystrophy (CORD).

Modified muscle transposition procedure for a case of inferior rectus muscle aplasia.

Purpose: We report a case of inferior rectus muscle aplasia in a 65-year-old woman.

Methods: Images were obtained using ocular motility photography and magnetic resonance imaging (MRI), and operative findings were analyzed.

Results: A 65-year-old woman presented with marked right hypertropia.