Pediatric-Onset Multiple Sclerosis and Primary Headache: Is There a Link?

Background: Pediatric-onset multiple sclerosis (POMS) is a rare but often more aggressive form of multiple sclerosis, associated with early cognitive impairment and significant impact on quality of life. Multiple sclerosis and primary headaches, particularly migraine, are well established in adults, but data on pediatric populations remain limited.

Methods: The purpose of this retrospective study was to examine 64 POMS patients, divided into groups with and without headaches, to determine potential correlations between headache presence, age at POMS onset, and MRI lesion burden.

Sleep-related painful erection: the first case in a child.

Unlabelled: Sleep-related painful erections are a rare sleep disorder characterized by recurrent nocturnal painful penile erections, typically occurring during rapid eye movement sleep, without associated pain during daytime erections. Although approximately 100 cases have been described in adult males, there are no reports of sleep-related painful erections in childhood. We present the case of a male infant born at 36 weeks' gestation, who began experiencing sleep-related painful erections and nocturnal awakenings in his first year of life.

Alternating Hemiplegia of Childhood: Understanding the Genotype-Phenotype Relationship of ATP1A3 Variations.

Alternating hemiplegia of childhood (AHC) is a rare neurological disorder affecting children with an onset before 18 months. Diagnostic clues include transient episodes of hemiplegia alternating in the laterality or quadriparesis, nystagmus and other paroxysmal attacks as tonic and dystonic spells. Epilepsy is also a common feature.