Parvovirus B19-associated myocarditis in children: A systematic review of clinical features, management and outcomes.

Background: Parvovirus B19 (PVB19) has emerged as a relevant etiologic agent of paediatric myocarditis, particularly during recent epidemiological surges in Europe and the United States. Despite increasing recognition, current knowledge remains fragmented, and standardised diagnostic and therapeutic strategies are lacking.

Methods: We conducted a systematic review of the literature up to May 2025, including 40 studies encompassing 53 individual case reports, 107 patients from registry-based cohorts, and 4 tissue-based investigations.

When coronary spasm strikes: a case report on the dreadful association between cannabinoids and caffeine.

Background: Coronary artery spasm (CAS) is a temporary, severe narrowing of the coronary arteries typically presenting with nitrate-responsive angina at rest, transient ischaemic ECG changes, and in some cases leading to silent myocardial ischaemia, acute myocardial infarction, life threatening arrhythmias and cardiac arrest.

Case Summary: A 47-years-old man with a history of chronic coronary syndrome and a working diagnosis of probable pheochromocytoma was admitted to the Emergency Department after two episodes of out-of-hospital cardiac arrest successfully resuscitated. Transient ST segment elevation was observed, and emergency coronary angiography (CA) revealed no significant coronary stenosis.

Assessment of the performances and limitations of spacetime convective corrections for acoustic metacontinua design.

The acoustic metamaterial extension to aeroacoustic applications is still an open issue principally due to the lack of a reliable methodology for the meta-devices design when they have to operate in a non-quiescent medium. One suitable strategy is to use spacetime coordinate transformations that include the background flow features to tune the meta-device design parameters analytically, and, therefore, the phenomenon must be reinterpreted into the spacetime. However, a change of coordinates capable of including all the convective effects is not known for general flow conditions and analytical approximations are inevitably introduced.

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy.

Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV). Guideline recommended medical therapy for HF, including angiotensin-converting enzyme inhibitors/angiotensin receptors II blockers/angiotensin receptor blocker-neprilysin inhibitors (ACE-I/ARB/ARNI), beta-blockers, mineralocorticoid receptor antagonists (MRA) and sodium-glucose transport protein 2 inhibitors (SGLT2i), have shown to improve morbidity and mortality in patients with HFrEF.

Estimation of Right Atrial Pressure by Ultrasound-Assessed Jugular Vein Distensibility in Patients With Heart Failure.

Background: Clinical evaluation of central venous pressure is difficult, depends on experience, and is often inaccurate in patients with chronic advanced heart failure. We assessed the ultrasound-assessed internal jugular vein (JV) distensibility by ultrasound as a noninvasive tool to identify patients with normal right atrial pressure (RAP ≤7 mm Hg) in this population.

Methods: We measured JV distensibility as the Valsalva-to-rest ratio of the vein diameter in a calibration cohort (N=100) and a validation cohort (N=101) of consecutive patients with chronic heart failure with reduced ejection fraction who underwent pulmonary artery catheterization for advanced heart failure therapies workup.

Guideline-directed medical therapy in severe heart failure with reduced ejection fraction: An analysis from the HELP-HF registry.

Aim: Persistent symptoms despite guideline-directed medical therapy (GDMT) and poor tolerance of GDMT are hallmarks of patients with advanced heart failure (HF) with reduced ejection fraction (HFrEF). However, real-world data on GDMT use, dose, and prognostic implications are lacking.

Methods And Results: We included 699 consecutive patients with HFrEF and at least one 'I NEED HELP' marker for advanced HF enrolled in a multicentre registry.