Publications by authors named "Ghanyah H Al-Qadami"
Article Synopsis
- - Oral mucositis (OM) is a significant side effect of cancer therapy, affecting up to 80% of patients, and is characterized by the destruction of epithelial cells and increased inflammation, creating a favorable environment for infections.
- - Research is examining how changes in the oral microbiome may be linked to the development and severity of OM, beyond just opportunistic infections, through 16S rRNA gene sequencing in cancer patients.
- - The review emphasizes the potential for targeting the microbiome as a therapeutic strategy in managing OM and discusses whether microbiome changes are causes or effects of mucosal damage.
The gut microbiota has emerged as a key modulator of cancer treatment responses in terms of both efficacy and toxicity. This effect is clearly mediated by processes impacting the activation and modulation of immune responses. More recently, the ability to regulate chemotherapeutic drug metabolism has also emerged as a key driver of response, although the direct mechanisms have yet to be fully elucidated.
View Article and Find Full Text PDFFecal microbiota transplant (FMT) is a powerful tool used to connect changes in gut microbial composition with a variety of disease states and pathologies. While FMT enables potential causal relationships to be identified, the experimental details reported in preclinical FMT protocols are highly inconsistent and/or incomplete. This limitation reflects a current lack of authoritative guidance on reporting standards that would facilitate replication efforts and ultimately reproducible science.
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