Publications by authors named "Gerardo Arroyo-Martinez"
Lung cancer remains the most common malignancy independent of sex. Here, we focused on unraveling the molecular mechanisms of CaS nanoclusters inducing cytotoxicity by investigating DNA damage, the cell cycle, oxidative stress, and cellular repair mechanisms in non-small-cell lung carcinoma (NSCLC) cells compared to healthy lung fibroblasts. Our previous studies have demonstrated the therapeutic potential of calcium sulfide (CaS) nanostructures in skin and breast cancer models, leading to a significant reduction in cancer cell proliferation.
View Article and Find Full Text PDFThe phosphatidylinositol 3' kinase (PI3K)-related kinase ATR is crucial for mammalian meiosis. ATR promotes meiotic progression by coordinating key events in DNA repair, meiotic sex chromosome inactivation (MSCI), and checkpoint-dependent quality control during meiotic prophase I. Despite its central roles in meiosis, the ATR-dependent meiotic signaling network remains largely unknown.
View Article and Find Full Text PDFArticle Synopsis
- DNA damage response mechanisms are crucial for successful gamete formation during meiosis, ensuring proper repair of double-strand breaks (DSBs).
- The study highlights that while RAD9A-RAD1-HUS1 (the canonical 9-1-1 complex) is important for DSB repair, mammalian meiocytes also use RAD9B and HUS1B as alternative components that can form different 9-1-1 complexes.
- Disruption of the RAD1 subunit in mice led to severe infertility issues, including poor DSB repair, depletion of germ cells, and defects in key meiotic processes such as homolog synapsis and sex chromosome inactivation.