Publications by authors named "Gentaro Egusa"
Clinical characteristics of Japanese Americans with normal glucose tolerance with 1-h hyperglycemia: A cross-sectional study.
J Diabetes Investig
September 2025
Aims/introduction: High 1-h plasma glucose levels have an increased risk of type 2 diabetes. To determine the pathophysiological features in participants with normal glucose tolerance (NGT) with 1-h hyperglycemia (HG), we investigated the variability in the glucagon and insulin secretions after oral glucose loading and nutrient survey.
Materials And Methods: A 75-g oral glucose tolerance test (OGTT) was performed in Japanese Americans (aged 40-75 years), enrolled in medical surveys conducted in 2015.
Article Synopsis
- Protein-protein interactions (PPIs) are crucial for many biological functions, and understanding them is essential for studying how proteins work.
- The study proposes a straightforward method to assess PPI using mammalian cells, involving introduction of expression vectors, cell lysis, and protein isolation with an affinity gel.
- The researchers also suggest using affinity antibodies to confirm PPIs, highlighting the importance of maintaining protein integrity throughout the process for accurate results.
Article Synopsis
- * Long-term use of stimulants to maintain their function can have undesirable side effects, making PPARα a better target for preserving beige adipocytes.
- * Pemafibrate, a medication used for treating dyslipidemia, has been shown to enhance the thermogenic ability of these cells, reduce body weight gain, and improve glucose tolerance in obese mouse models.