Effects of nonstationary system blur on radiomic texture features of trabecular bone in normal and ultra-high resolution CT.

Background: CT image texture features (TFs) of trabecular bone are being investigated as predictive markers in osteoporosis (OP) and osteoarthritis (OA). To support the development of such radiomic approaches, the reproducibility of bone TFs to CT system factors needs to be characterized. We hypothesize that, in addition to the well-established inter- and intra-scanner effects (e.

Macroscopic differences in adult human femora are linked to body mass index.

Bone functional adaptation is routinely invoked to interpret skeletal morphology despite ongoing debate regarding the limits of the bone response to mechanical stimuli. The wide variation in human body mass presents an opportunity to explore the relationship between mechanical load and skeletal response in weight-bearing elements. Here, we examine variation in femoral macroscopic morphology as a function of body mass index (BMI), which is used as a metric of load history.