Evaluation of visual function and OCT parameters in ethambutol-induced optic neuropathy: a longitudinal study.

Aims: To evaluate structural and visual functional parameters in ethambutol-related toxic optic neuropathy (EON).

Methods: In this prospective study, we recruited 95 adults with EON presenting within 1 month of onset and 100 age-matched healthy controls. Best-corrected visual acuity (Early Treatment Diabetic Retinopathy Study chart), colour vision (Ishihara pseudoisochromatic plates), contrast sensitivity (Pelli-Robson chart), Humphrey visual field analysis (HVF 30-2 Swedish Interactive Threshold Algorithm-FAST), visual evoked response and spectral domain optical coherence tomography for macular ganglion cell-inner plexiform layer (mGC-IPL), retinal nerve fibre layer (RNFL) and papillomacular bundle (PMB) analyses were done at baseline, 3 months and 6 months.

Endocrine Prehabilitation.

We conceptualize and define endocrine and metabolic prehabilitation as enhancement of physical, psychosocial and social health, prior to a planned medical, surgical or radiotherapeutic endocrine/metabolic intervention, in order to ensure optimal therapeutic outcomes during and after the procedure. This is similar to, but different from the process of endocrine rehabilitation, which follows endocrine therapy. All health care professionals, working as a team, should take responsibility of endocrine prehabilitation.

Early onset unilateral Terrien's marginal degeneration.

A young man in his first decade of life presented with insidious onset, gradually progressive diminution of vision in right eye since 2 months associated with foreign body sensation. Slit-lamp examination revealed superior arcuate band of corneal stromal thinning extending from 9-3 o' clock. There was associated corneal vascularisation and presence of lipid deposition at the leading edge of the furrow formation with intact epithelium without any apparent signs of inflammation.

Incidence, short-term outcome, and spatial distribution of stroke patients in Ludhiana, India.

Objective: To estimate the incidence, short-term outcome, and spatial distribution of stroke patients and to evaluate the completeness of case ascertainment in Ludhiana.

Methods: This population-based prospective cohort study was conducted in Ludhiana, Punjab, Northwest India. All first-ever stroke patients (≥18 years) were included between March 2010 and March 2013 using WHO Stepwise Approach Surveillance methodology from the city.

SPAAN: a software program for prediction of adhesins and adhesin-like proteins using neural networks.

Motivation: The adhesion of microbial pathogens to host cells is mediated by adhesins. Experimental methods used for characterizing adhesins are time-consuming and demand large resources. The availability of specialized software can rapidly aid experimenters in simplifying this problem.