Publications by authors named "Gabriele Arduino"
Advances in the management of bipolar disorder in children and adolescents: an update on the literature.
Expert Rev Neurother
October 2024
Article Synopsis
- Early diagnosis and treatment of bipolar disorder (BD) in youths lead to improved long-term outcomes, yet about one-third of affected patients do not receive adequate medication.
- The authors review current literature on managing BD in children and adolescents, primarily focusing on the effectiveness and side effects of various pharmacological treatments.
- Key findings indicate that while D2-blockers may have adverse effects, lurasidone is effective for acute juvenile bipolar depression, and lithium is beneficial for managing manic episodes; anticonvulsants are helpful as additional treatments for those not responding to first-line therapies, with no support for antidepressants in juvenile BD.
Immunomodulatory Effects of Clozapine: More Than Just a Side Effect in Schizophrenia.
Curr Neuropharmacol
May 2024
Article Synopsis
- - Recent research indicates a potential link between the immune system and schizophrenia spectrum disorders (SSDs), highlighting the role of neuroinflammation as both a protective response and a factor in chronic conditions that can lead to brain dysfunction.
- - Microglia, the immune cells in the brain, have been identified as significant contributors to various neurodegenerative diseases and may play a role in the inflammatory processes associated with SSDs.
- - The article reviews the effects of certain treatments, like clozapine and nonsteroidal anti-inflammatory drugs, which may help alleviate symptoms of SSDs by modulating immune responses in the brain.
Clozapine in a Young Female with Drug-Resistant Schizophrenia: A Case Report of Development of Serositis.
CNS Neurol Disord Drug Targets
December 2022
Background: Clozapine may be considered the first-line option for treatment-resistant schizophrenia (TRS), a condition that occurs in more than 30% of patients with schizophrenia. Despite its efficacy for treating TRS, clozapine use is limited by the occurrence of several adverse effects in more than 70% of cases. Clozapine does not typically affect lung function, although a few cases have been reported in the literature.
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