In Vivo Evaluation of NLRP3 Inflammasome and IL-1β Cytokine in Periapical Lesion Progression Using Wild-Type and TLR2 Knockout Mice.

This study aimed to investigate the role of Toll-like receptor 2 (TLR2) in the progression of periapical lesions by evaluating NLRP3 inflammasome and interleukin-1 beta (IL-1β) expression in wild-type (WT) and TLR2 knockout (KO) mice. A total of 55 mice (28 WT, 27 TLR2-KO) underwent pulpal exposure of mandibular first molars and were euthanised at 7, 21, or 42 days post-exposure. Histological and immunohistochemical analyses were performed.

Ulectomy in a patient with nephrotic syndrome under investigation for Galloway-Mowat syndrome: a case report.

The aim of this study is to report a case in which a patient with nephrotic syndrome underwent surgery to remove fibrous gum tissue (ulectomy). An 8-year-old patient, diagnosed with early onset nephrotic syndrome due to a mutation in the NUP107 gene, had received a kidney transplant and was therefore taking various medications, including immunosuppressants. On oral examination, the patient was found to have a fibrous gingiva that was preventing the eruption of the upper permanent central incisors.