Publications by authors named "Ga-Hee Ryoo"
Article Synopsis
- Twenty-one dihydropyranocoumarins and one furanocoumarin were isolated from the flowers of Peucedanum japonicum, including four new compounds.
- The structures and stereochemistry of the new compounds were determined using advanced techniques like nuclear magnetic resonance and mass spectroscopy.
- The isolated compounds were tested for their ability to inhibit aldo-keto reductase 1C1 in lung cancer cells, with compounds 10 and 12 showing notable inhibitory activity.
Article Synopsis
- Wheat is the second most cultivated food crop globally, known for its high carbohydrate content and nutritional benefits, but it also produces a significant amount of hull as a non-food by-product.
- Researchers studied hulls from gamma-irradiated mutant lines of cultivated wheat to extract functional components, using advanced mass spectrometry techniques to identify a total of 55 metabolites, including 21 compounds never seen before in wheat.
- They identified 10 metabolites as key markers with anti-inflammatory properties, suggesting that wheat hull is a promising source for beneficial tricin-lignan compounds.
Article Synopsis
- * A study analyzed the PC content in 91 wheat sprout samples, including mutant lines created through gamma-irradiation, revealing that 18 of the mutant lines had higher PC content than the original variety.
- * Cultivating these mutant lines under white LED light was more effective for maximizing PC production than using colored LED lights, highlighting the potential of these wheat varieties as functional foods for managing cholesterol and promoting health.
Antimetastatic activity of seongsanamide B in γ-irradiated human lung cancer.
Heliyon
September 2023
Lung cancer, which has a high incidence and mortality rates, often metastasizes and exhibits resistance to radiation therapy. Seongsanamide B has conformational features that suggest it has therapeutic potential; however, its antitumor activity has not yet been reported. We evaluated the possibility of seongsanamide B as a radiation therapy efficiency enhancer to suppress γ-irradiation-induced metastasis in non-small cell lung cancer.
View Article and Find Full Text PDF(Umbelliferae) is widely distributed throughout Southeast Asian countries. The root of this plant is used in traditional medicine to treat colds and pain, whereas the young leaves are considered an edible vegetable. In this study, the differences in coumarin profiles for different parts of including the flowers, roots, leaves, and stems were compared using ultra-performance liquid chromatography time-of-flight mass spectrometry.
View Article and Find Full Text PDFSupplementation with Jingzaojing Leaf and Shoot Extract Improves Exercise Endurance in Mice.
Nutrients
September 2022
Article Synopsis
- This study explores how the extract from Jingzaojing leaves and shoots (JLSE), containing phenolic compounds, impacts muscle fiber type switching from fast-glycolytic to slow-oxidative fibers, which could help with heart and metabolic diseases.
- Male mice were given JLSE or a placebo and trained on a treadmill for four weeks, resulting in those given JLSE displaying better stamina and mitochondrial function.
- JLSE helped promote this muscle fiber shift by increasing the expression of a protein called sirtuin 6 and decreasing another called Sox6, leading to more mitochondria and improved exercise endurance.
Article Synopsis
- NAD is a crucial cofactor for various biological processes, and its decline with age impairs immune function, particularly in mast cells during anaphylaxis, a topic that hasn't been extensively studied.
- The study investigated the impact of NAD-boosting compounds, namely nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), on mast cell activity and anaphylactic responses in both human and mouse models.
- Results showed that NAD precursors reduced harmful signaling and inflammatory responses in mast cells and significantly decreased anaphylactic reactions in mouse models, though these effects depended on the presence of the Sirt6 protein in mast cells.
Tussilagone promotes osteoclast apoptosis and prevents estrogen deficiency-induced osteoporosis in mice.
Biochem Biophys Res Commun
October 2020
Osteoporosis is a degenerative disease characterized by reduced bone mass, in which deregulated bone remodeling by osteoclasts and osteoblasts is a main pathogenesis. Although recently tussilagone, a major active component of flower buds of Tussilago farfara, has been shown to inhibit osteoclastogenesis, its effect on estrogen deficiency-induced osteoporosis remains unknown. This study examined the effect of tussilagone on bone loss in ovariectomized mice and further explored its impact on osteoclast apoptosis and osteoblast formation in addition to osteoclastogenesis.
View Article and Find Full Text PDFAdipose tissue inflammation is a reproducible feature of obesity and obesity-linked insulin resistance. Although sirtuin 6 (Sirt6) deficiency has previously been implicated in diet-induced obesity and systemic insulin resistance, the adipocyte-specific role of Sirt6 in the regulation of adipose tissue inflammation and systemic metabolic dysfunction in mice fed normal chow and in humans remains elusive. Here, using Adipoq-Cre-mediated adipocyte-specific Sirt6 knockout (aS6KO) mice, we explored whether adipocyte Sirt6 inhibits adipose tissue inflammation and its underlying mechanism.
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