Thorough Lymphadenectomy Impairs Immunotherapy Outcomes for Postoperative Intrathoracic Recurrence of Non-small Cell Lung Cancer.

Background/aim: Immune checkpoint inhibitors (ICIs) have emerged as a standard treatment for recurrent non-small cell lung cancer (NSCLC). However, the factors predicting their efficacy in postoperative recurrence remain unclear.

Patients And Methods: We retrospectively analyzed 30 patients who underwent complete surgical resection of NSCLC and subsequently received ICI monotherapy for recurrence.

Local Recurrence After Sublobar Resection for Primary Lung Cancer: Does the Type of Stapling Device Matter?

Objectives: Two major types of stapling devices exist: those with disposable built-in knives and those with nondisposable built-in knives. This study investigated whether the stapler type influences the incidence of local recurrence, including margin recurrence and pleural dissemination, after curative sublobar resection for lung cancer.

Methods: We retrospectively reviewed patients who underwent sublobar resection at our institution between 2010 and 2021.

Importance of future motivation for skill acquisition among medical students undergoing endoscopic forceps training.

Background: In recent years, surgical procedures have shifted from open thoracotomy and laparotomy to minimally invasive endoscopic surgery, making endoscopic forceps training essential. In our department, we teach endoscopic forceps training to medical students in dry laboratories. We examined differences in the skill acquisition of medical students undergoing endoscopic forceps training.

Topohistology of dendritic cells and macrophages in the distal and proximal nodes along the lymph flow from the lung.

Nodal dendritic cells and CD169-positive macrophages cross-present cancer antigens earlier in the proximal nodes than in the distal nodes along the lymph flow from cancer. We examined topohistological differences between the proximal and distal nodes before the formation of metastasis. Immunohistochemical and morphometric analyses were performed to examine DC-SIGN-, CD68-, and CD169-positive cells in the subcarinal node (proximal) and paratracheal nodes (distal nodes) from 16 patients with lower-lobe lung cancer without metastasis (adenocarcinoma, 11; squamous, 5).

Association between left atrial function and pulmonary vein stump thrombus after left upper lobectomy: insights from cine-MRI.

The purpose of this study is to evaluate left atrial function using cine-magnetic resonance imaging (cine-MRI) in patients with pulmonary vein stump thrombus (PVST) after left upper lobectomy (LUL). The study population comprised 91 patients (30 with PVST and 61 without PVST) who underwent LUL for pulmonary lesions and evaluation by cine-MRI. Left atrial functional parameters were evaluated and compared between patients with and without the development of PVST after LUL using the Mann-Whitney U test.