Quality of Life in patients with Overt Hypothyroidism. A systematic review.

Objective: Persistent symptoms and impaired quality of life(QoL) in hypothyroidism despite treatment with levothyroxine(LT4) receive increasing attention. We aimed at reviewing QoL in long-termly treated hypothyroidism.

Design: Systematic review and meta-analysis.

Altered amyloid plasma profile in patients with disabling headaches after SARS-CoV-2 infection and vaccination.

Background And Objectives: Persistent headache has emerged as a symptom following acute COVID-19 and, to a lesser extent, after SARS-CoV-2 vaccination. However, the underlying mechanisms remain poorly understood. This study aimed to evaluate plasma levels of amyloid-related biomarkers in patients experiencing persistent headaches after COVID-19 or SARS-CoV-2 vaccination.

Correlates of SARS-CoV-2 Breakthrough Infections in Kidney Transplant Recipients Following a Third SARS-CoV-2 mRNA Vaccine Dose.

Background: Kidney transplant recipients (KTRs) exhibit a significantly diminished immune response to Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) vaccines compared with the general population, primarily due to ongoing immunosuppressive therapy. This study evaluated the immunogenicity of a third SARS-CoV-2 mRNA vaccine dose in KTRs and assessed the association between antibody response and protection against SARS-CoV-2 breakthrough infection. Additionally, the clinical and immunological correlates of post-vaccination SARS-CoV-2 infection were examined.

Sex-specific cortical brain differences in children at familial high risk for schizophrenia or bipolar disorder.

Background: Familial high risk (FHR) is the strongest predictor of developing schizophrenia (SZ) and bipolar disorder (BP). Children at FHR uniquely allow for identifying early brain markers of vulnerability. Previous studies often span wide age ranges and neglect sex differences, despite evidence of distinct sex-specific brain developmental trajectories.

A Pilot Validation Study of a Biomechanical Simulation Model for Rotational Ankle Injuries Using Robotic Cadaveric Testing.

Background: Deltoid ligament injuries occur in specific sequences during rotational ankle trauma, yet the current understanding of these sequences may be flawed. Computer modeling offers a new method for assessing ligament behavior under rotational injury mechanisms.

Methods: A biomechanical computer simulation model was developed using AnyBody Modeling Software to evaluate ligament strain in rotational ankle injuries.

High risk of bloodstream infections, diverse causal pathogens, and association with haemodialysis and plasma exchange in ANCA-associated vasculitis.

Objectives: Infections from immunosuppressive treatment are a major cause of hospitalisation and mortality in ANCA-associated vasculitis (AAV). This study examines bloodstream infections (BSIs) in incident AAV patients, comparing incidence, bacterial distribution, and risk to the general population, with emphasis on central venous catheters (CVCs).

Methods: Using Danish nationwide registries, we studied patients diagnosed from 2010 to 2018, followed until first BSI, death, or a maximum of five years.

Mechanobiology of gastric needle insertions: a combined experimental and numerical study.

The rising use of biologic drugs has increased the demand for alternative gastric administration methods. Inception of devices engineered to insert medication into the mucosal lining overcomes limitations of traditional administration methods. Mechanical forces from such microneedle insertions can affect tissue and cellular behavior, particularly mechanotransduction markers.

Exploring whey and faba bean protein interactions at the oil-water interface: A combined drop tensiometry and microfluidicsstudy.

The interfacial properties of model oil-water interfaces stabilized by faba bean protein isolate (FPI), whey protein isolate (WPI), and their mixtures were investigated. Two complementary techniques, microfluidics-based analysis and drop tensiometry were employed to study the impact of protein mixing on interfacial tension, adsorption kinetics, and droplet stability. A microfluidic platform was used for droplet generation and single droplet analysis, assessing the impact of protein blending on droplet size and shape eccentricity after droplet generation.

A Quinolinium-Functionalized Hemicyanine Dye for Ratiometric NAD(P)H Sensing in Live Cells, Kidney Tissues, and Drosophila melanogaster.

NAD (Nicotinamide adenine dinucleotide) and NADP (its phosphorylated variation) are key coenzymes regulating cellular metabolism, biosynthesis, and redox balance. Variations in NAD(P)H activity reflect metabolic activity and are associated with diseases like cancer, metabolic disorders, and neurodegeneration. Live tracking of NAD(P)H is important for comprehending these processes and their dysregulation in disease.

Digital assistive technologies for community-dwelling people with dementia: A systematic review of systematic reviews by the INTERDEM AI & assistive technology taskforce.

Introduction: The use of digital assistive technologies by and for people living with dementia is promising for supporting social health and advocated as a partial solution to growing prevalence worldwide. A state-of-the-art position paper published in 2017 identified challenges regarding digital assistive technologies, around five themes: development, usability, (cost-)effectiveness, implementation and ethics. This systematic review summarizes progress on the challenges found in 2017, and persisting or emerging challenges.

SCFMUNet: A fusion architecture based on multi-scale state space model and channel attention for medical image segmentation.

Medical image segmentation is essential for disease diagnosis and therapy planning, but the complexity of multi-organ structures and blurred skin lesion boundaries poses challenges. CNNs and Transformers are constrained by limited receptive fields and high computational complexity. The state-space model effectively captures long-range dependencies with linear complexity but struggles with local modeling and channel attention.

Multi-scale interaction and locally enhanced bridging network for medical image segmentation.

Accurate organ segmentation is crucial for precise medical diagnosis. Recent methods in CNNs and Transformers have significantly enhanced automatic medical image segmentation. Their encoders and decoders often rely on simple skip connections, which fail to effectively integrate multi-scale features.

High-amylose barley bread improves postprandial glycemia compared to regular barley and wheat bread in subjects with or without type 2 diabetes.

Background: Genetically modified (GMO) high-amylose barley lowers postprandial glucose. Since certain EU countries do not allow GMO barley, we therefore assessed if high-amylose barley made from traditional breeding (Lean Baking Barley, LBB) lowers postprandial glucose compared to bread made from regular barley (RB) or wheat (WF) in individuals with or without type 2 diabetes (T2D).

Methods: In a randomised crossover design, 38 participants (18 T2D and 20 non-T2D) consumed 160 g of bread made from 100% LBB, RB, or WF.

A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines.

DNA repair disorders are a group of conditions characterized by progressive, multisystem phenotypes. Defining new clinical presentations of these disorders is essential for optimizing patient care. ERCC1-XPF is a multifunctional endonuclease involved in nucleotide excision repair (NER) and interstrand crosslink (ICL) repair.

Optimizing Prevention of Recurrent Urinary Tract Infections in Older Patients with Frailty.

Frailty is associated with impaired immune function, functional decline, and increased vulnerability to both infection and adverse medication effects. Recurrent urinary tract infection (rUTI) is a common and burdensome condition among older persons, particularly those living with frailty. Despite this, frail individuals remain underrepresented in clinical research guiding rUTI prevention.

Origins and diversity of Greenland's revealed with genomes of ancient and modern sled dogs.

The (Greenland sled dog) has worked continuously with the Inuit in Greenland for more than 800 years. However, they now face drastic population declines caused by climate change, urbanization, and competition from snowmobiles. This study sequenced 92 modern and ancient genomes to investigate how centuries of isolation shaped the regional populations and the impact of European contact.

Using must-have and can-have features to improve conceptual learning.

Concepts can be taught by presenting examples and nonexamples and giving the learner feedback on whether they accurately identify the examples, but it is not clear how to select examples and nonexamples. Specifically, the degree to which examples and nonexamples should differ is unknown. Six experiments were conducted to compare conceptual learning for four stimulus sets (three sets of arbitrary stimuli and one set of biological stimuli) across up to three practice conditions: (a) nonexamples that were relatively similar to the examples, (b) nonexamples that were relatively dissimilar to the examples, and (c) examples only.

Standardisation and Optimisation of Chest and Pelvis X-Ray Imaging Protocols Across Multiple Radiography Systems in a Radiology Department.

X-ray imaging protocols in radiology departments often exhibit variability in exposure parameters and geometric setups, leading to inconsistencies in image quality and potential variations in patient dose. : This study aimed to harmonise and optimise chest and pelvis X-ray imaging protocols by standardising exposure parameters and geometric setups across departmental systems, minimising radiation dose while ensuring adequate image quality for accurate diagnosis. : The image quality of five pelvic and three chest protocols across different radiographic systems was evaluated both quantitatively and visually.

Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration.

Cellular senescence leads to stable cell cycle arrest and an inflammatory senescence-associated secretory phenotype that varies with stressor and cell type. To mitigate these effects and improve health, senotherapeutics (e.g.

Digital PCR enables direct root biomass quantification and species profiling in soil samples.

Roots support plant growth and resilience and are a major route for carbon sequestration. Thus, the study of roots in agricultural and natural systems is essential to develop strategies to mitigate and adjust to climate change. Methods to quantify root biomass in mono- and mixed crop systems are therefore in high demand.

Upper-Limb Complications in Diabetes: A Narrative Review.

Upper-limb complications (ULCs) in diabetes, affecting joints, tendons, muscles, connective tissue, nerves, and skin, are underrecognized but prevalent conditions in type 1 and type 2 diabetes. Advances in diabetes care have extended life expectancy, leading to an aging population with diabetes with increased susceptibility to long-term complications beyond traditional vascular issues. Despite some data on ULCs epidemiology, understanding of their pathogenesis, prevention, and impact on quality of life remains limited, and treatments are often based on clinical experience rather than robust evidence.

Impact of Obesity on Treatment Response in Patients With Chronic Inflammatory Disease Receiving Biologic Therapy: Secondary Analysis of the Prospective Multicentre BELIEVE Cohort Study.

Biological therapy is used to treat chronic inflammatory diseases (CIDs); however, up to 50% of patients fail to achieve an adequate clinical response. This study aimed to access the impact of obesity on clinical treatment response in CID patients after 14-16 weeks of biological therapy. This multicentre prospective cohort study enrolled 233 adults between 2017 and 2020 diagnosed with Crohn disease, ulcerative colitis (UC), rheumatoid arthritis, axial spondyloarthritis (PsA), psoriatic arthritis or psoriasis scheduled for biologic therapy.

Effects of Fibular Plate Fixation and Deep Posterior Tibiotalar Ligament Repair on Ankle Stability in a Weber B Fracture Model with Complete Deltoid Ligament Sectioning.

Background: Weber B (supination external rotation) ankle fractures with complete deltoid ligament rupture (SER4b) are typically considered unstable and treated with plate fixation of the fibula. Recent studies have suggested a significant ankle-stabilizing role of the deep posterior tibiotalar ligament (dPTTL), which questions current practice. To our knowledge, there are few studies on the biomechanical effects of plate fixation and none on dPTTL repair.