Transactional models of depression via caregiver-child interactions: Evaluating conflict resolution as a source of resilience in adversity-exposed families.

Background: Youth who experienced early life caregiving adversity (ECA) are at increased risk for developing depression, which may in part reflect a heightened vulnerability to the deleterious effects of later-life stressors, including poor caregiver mental health and interpersonal conflict. Transactional models posit bidirectional influences between caregivers and children that operate over development and more proximally across interactions.

Objective: To address gaps in knowledge of bidirectional influences between caregivers and children, and differences therein based on ECA exposure, we evaluated the effects of caregiver and child depressive symptoms on their own and each other's emotion-related behavior during conflict resolution, and the effects of their behavior on their own and each other's changes in affect expression from conflict resolution to a recovery task.

The mind, brain, and body study: A protocol for examining the effects of the gut-brain-immune axis on internalizing symptoms in youth exposed to caregiving-related early adversity.

Experiences of caregiving-related adversity are common and one of the strongest predictors of internalizing psychopathology (i.e., anxiety and depression).

Characteristics of the oral microbiome in youth exposed to caregiving adversity.

Caregiving adversity (CA) exposure is robustly linked to increased risk for poor oral, physical, and mental health outcomes. Increasingly, the gut microbiome has garnered interest as a contributor to risk for and resilience to such health outcomes in CA-exposed individuals. Though often overlooked, the microbiome of CA-exposed individuals may be just as important a contributor to health outcomes as the gut microbiome.

A comparison of the infant gut microbiome before versus after the start of the covid-19 pandemic.

The COVID-19 pandemic and resulting public health directives led to many changes in families' social and material environments. Prior research suggests that these changes are likely to impact composition of the gut microbiome, particularly during early childhood when the gut microbiome is developing most rapidly. Importantly, disruption to the gut microbiome during this sensitive period can have potentially long-lasting impacts on health and development.

Multigenerational adversity impacts on human gut microbiome composition and socioemotional functioning in early childhood.

Adversity exposures in the prenatal and postnatal period are associated with an increased risk for psychopathology, which can be perpetuated across generations. Nonhuman animal research highlights the gut microbiome as a putative biological mechanism underlying such generational risks. In a sample of 450 mother-child dyads living in Singapore, we examined associations between three distinct adversity exposures experienced across two generations-maternal childhood maltreatment, maternal prenatal anxiety, and second-generation children's exposure to stressful life events-and the gut microbiome composition of second-generation children at 2 y of age.

A Translational Approach to the Mind-Brain-Body Connection.

Mental and physical health are closely tied, and a deeper understanding of how the mind, brain, and body are connected has the potential to substantially improve health outcomes. In particular, a translational approach that integrates research on mind-brain-body connections at multiple levels of analysis (e.g.

White matter myelination during early infancy is linked to spatial gradients and myelin content at birth.

Development of myelin, a fatty sheath that insulates nerve fibers, is critical for brain function. Myelination during infancy has been studied with histology, but postmortem data cannot evaluate the longitudinal trajectory of white matter development. Here, we obtained longitudinal diffusion MRI and quantitative MRI measures of longitudinal relaxation rate (R1) of white matter in 0, 3 and 6 months-old human infants, and developed an automated method to identify white matter bundles and quantify their properties in each infant's brain.

Infants' cortex undergoes microstructural growth coupled with myelination during development.

Development of cortical tissue during infancy is critical for the emergence of typical brain functions in cortex. However, how cortical microstructure develops during infancy remains unknown. We measured the longitudinal development of cortex from birth  to six months of age  using multimodal quantitative imaging of cortical microstructure.

Dimensions of the language environment in infancy and symptoms of psychopathology in toddlerhood.

The quality of the early environment influences the development of psychopathology. Children who are deprived of sufficient environmental enrichment in infancy may be at higher risk for developing symptoms of psychopathology in toddlerhood. In this study, we investigated the prospective association between naturalistic measures of adult language input obtained through passive monitoring of infants' daily environments and emerging psychopathology in toddlerhood.

In a father's mind: paternal reflective functioning, sensitive parenting, and protection against socioeconomic risk.

This study utilized attachment theory as a framework for understanding how fathers' reflective functioning (RF) and social emotional (SE) and autonomy (AU) supportive behaviors relate to children's emotion regulation (ER) beyond effects of mothers' RF. Moreover, the study explored how fathers' RF may be a protective factor against risks associated with low income. Fathers (n = 77) and their toddlers participated.