Discovery of a novel lymphocytic choriomeningitis virus strain associated with severe human disease in immunocompetent patient, New Mexico.

Lymphocytic choriomeningitis virus (LCMV) is an underreported emerging pathogen and was recently included as a National Institute of Allergy and Infectious Disease (NIAID) priority pathogen. LCMV is an important cause of aseptic meningitis and has high morbidity and mortality during congenital and organ-transplant transmission. The house mouse, , is a reservoir for LCMV, and human infection occurs through exposure to aerosolized virus from the mouse excreta.

A longitudinal assessment of the antibody response to SARS-CoV-2 infection in the New Mexican population.

While many studies have assessed immune responses to SARS-CoV-2 infection, none have studied functional antibody responses before and after vaccination of exposed patients in New Mexico in the United States. Here, we evaluate antibody binding, antibody neutralization, and antibody dependent cell-mediated cytotoxicity (ADCC) responses from convalescent patients between September 2020 and April 2021. Our results indicate that binding, neutralizing, and ADCC titers remained durable over an estimated 4-month period or were boosted by vaccination.