Wearable microfluidic immunosensors for point-of-care detection of bio-analytes: a critical review.

Early and timely disease diagnosis is crucial for effective treatment and improved clinical outcomes. Antibodies and their fragments are among the most widely used affinity reagents in point-of-care (POC) assays because of their target specificity and affinity. Traditional immunosensors, the analytical devices utilizing antibodies as the biorecognition elements, are time-consuming and require advanced lab settings, limiting their use in POC testing.

Accelerated healing of full-thickness skin wounds by multifunctional exosome-loaded scaffolds of alginate hydrogel/PCL nanofibers with hemostatic efficacy.

Although employing exosomes (EXOs) for promoting tissue repair is already in the pipeline as a new cell-free wound treatment, the rapid clearance of EXOs is still a challenge. This study assesses the effectiveness of a hybrid design of nanofibers and hydrogel in the controlled delivery of EXOs to wounds for an enhanced healing process. EXOs are isolated from the human placenta-derived stem cells and characterized by a novel nano-fluorescent dot blot assay.

Engineered Robust Hydrophobic/Hydrophilic Nanofibrous Scaffolds with Drug-Eluting, Antioxidant, and Antimicrobial Capacity.

Multifunctional nanofibrous architectures have attracted extensive attention for biomedical applications due to their adjustable and versatile properties. Electrospun fabrics stand out as key building blocks for these structures, yet improving their mechanobiological and physicochemical performance is a challenge. Here, we introduce biodegradable engineered hydrophobic/hydrophilic scaffolds consisting of electrospun polylactide nanofibers coated with drug-eluting synthetic (poly(vinyl alcohol)) and natural (starch) polymers.