Protective Effects of as a Natural Remedy to Counteract Pregabalin-Induced Toxicity: Insights From Chemical Profiling, In Vivo, and In Silico Analyses.

This study explores the therapeutic potential of extract in alleviating pregabalin (PGB)-induced toxicity in male Wistar rats, with a focus on hepatic, renal, and reproductive health. PGB exposure led to significant biochemical disturbances, including elevated liver enzymes (AST, ALT, LDH), impaired kidney markers (urea, creatinine, uric acid), reduced reproductive hormones (testosterone, FSH, LH), and notable histopathological damage in liver, kidney, and testicular tissues. Treatment with extract effectively restored liver and kidney functions and partially corrected hormonal imbalances.