Publications by authors named "Femke Smit"
Obesity and cardiometabolic disease often, but not always, coincide. Distinguishing subpopulations within which cardiometabolic risk diverges from the risk expected for a given body mass index (BMI) may facilitate precision prevention of cardiometabolic diseases. Accordingly, we performed unsupervised clustering in four European population-based cohorts (Nāāā173,000).
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- Obesity is often viewed as a lifestyle choice rather than a disease, leading to initiatives like the IMI SOPHIA project, which aims to better categorize individuals with obesity based on their disease risk and treatment responses.
- SOPHIA faces challenges due to siloed clinical cohorts, which limit data sharing for biomarker discovery, but tackles this by using a federated database built on open-source DataSHIELD technology that integrates 16 different data sources.
- The project allows secure analysis of combined data without revealing individual patient information, demonstrated through a proof-of-concept analysis linking BMI and blood pressure, which showed results similar to traditional meta-analyses, setting a standard for safe collaborative research.
Audiovisual processing was studied in a functional magnetic resonance imaging study using the McGurk effect. Perceptual responses and the brain activity patterns were measured as a function of audiovisual delay. In several cortical and subcortical brain areas, BOLD responses correlated negatively with the perception of the McGurk effect.
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