Publications by authors named "Federico Biagi"
Background And Aims: Data on work absenteeism in celiac disease (CD) are scarce. This study aimed to evaluate the hours of work lost, reasons for work absenteeism, and their association with quality of life (QOL) and psychological morbidity in celiac patients on a gluten-free diet (GFD).
Methods: Adult celiac patients on a GFD were enrolled in a cross-sectional Italian study between October-2022 and October-2024.
A multicenter study on bowel preparation in inflammatory bowel disease patients: comparison between 1L-PEG-ASC and 2L-PEG regimens in an outpatient setting.
Eur J Gastroenterol Hepatol
October 2025
Background And Aims: There is a paucity of data on which bowel preparation (BP) to use in an inflammatory bowel disease (IBD) outpatient setting, in particular after the introduction of 1L-PEG-ASC. Thus, we aimed to evaluate the most effective BP between 1L-PEG-ASC and 2L-PEG and to identify risk factors for inadequate BP in this IBD population.
Methods: This is a multicentric, retrospective, cross-sectional study including IBD patients aged >16 years, who underwent outpatient split-dose colonoscopy between January 2021 and December 2022.
Gastroesophageal reflux disease (GERD) is a chronic condition that causes an abrupt decrease in salivary pH in the oral cavity, which can lead to demineralization, erosion, hypersensitivity, functional impairment, and possibly fracture of dental elements. The aim of this clinical study is to compare two types of treatment in patients with dental erosion diagnosed with gastroesophageal reflux. Thirty patients were enrolled in this randomized clinical trial.
View Article and Find Full Text PDFBackground And Aims: Inflammatory bowel diseases (IBD) are chronic conditions that can lead to a physical, social, and economic burden. Generative artificial intelligence (AI), particularly ChatGPT, gained attention for its potential to support medical practice. However, concerns remain about the reliability and consistency of its responses.
View Article and Find Full Text PDFBackground: Interest in a biopsy-sparing diagnosis of coeliac disease in adults is growing.
Aims: To develop and prospectively validate a non-invasive diagnostic strategy for adults with suspected coeliac disease based on clinical features and endomysial antibodies (EmA).
Methods: We retrospectively enrolled adults investigated for coeliac disease with EmA and duodenal biopsy between January 2000 and December 2021 in cohort 1 and stratified according to age at presentation (< 45 years; ≥ 45 years) and alarm symptoms.
Objective: Gastroesophageal reflux disease (GORD) is commonly reported in coeliac disease (CD). However, long-term data on GORD in coeliac patients on a gluten-free diet (GFD) are lacking. We aimed to evaluate the prevalence of GORD and endoscopic lesions in coeliac patients at diagnosis and throughout follow-up.
View Article and Find Full Text PDFBackground: The reported prevalence of coeliac disease (CD) in rheumatoid arthritis (RA) is variable.
Objective: To evaluate the prevalence and incidence of CD in RA and controls.
Design: Case-control study on administrative data.
Introduction: Long-term prognosis of nonceliac enteropathies (NCEs) is poorly understood. We aimed to evaluate long-term outcomes and develop a prognostic score for NCEs.
Methods: NCEs patients from an international multicenter cohort (4 Italian centers, 1 United Kingdom, 1 French, 1 Norwegian, 1 United States, 1 Indian) followed-up over 30 years were enrolled.
Coeliac disease is an immune-mediated chronic enteropathy, with a prevalence of around 1% in the general population and occurring in genetically susceptible individuals after the ingestion of gluten proteins present in wheat, rye and barley. Currently, a strict lifelong gluten-free diet is the cornerstone of treatment of coeliac disease. However, maintaining strict dietary adherence is challenging for many patients, due to the high costs, the highly restrictive nature of the diet and the impact on patients' quality of life.
View Article and Find Full Text PDFDiagnostic outcomes after gluten challenge in adult patients with unconfirmed coeliac disease already on a gluten-free diet: A 20-year retrospective cohort study.
Dig Liver Dis
April 2025
Background: In uncertain cases of coeliac disease (CD), gluten challenge (GC) may be necessary to confirm or exclude the diagnosis. However, data on diagnostic outcomes after GC are limited.
Aims: We aimed to evaluate outcomes after GC in patients with unconfirmed CD who had already started a gluten-free diet (GFD), and identify predictors of a confirmed diagnosis.
Background: Gastroenterologists still raise concerns about adopting a non-biopsy strategy for diagnosing celiac disease (CeD) in adults.
Aim: To assess the performance of the concurrent detection of two autoantibodies targeting two independent antigens, tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP).
Methods: This prospective, multicenter, binational study collected consecutive patients with a high pre-test probability for CeD.
Article Synopsis
- * The study included 177 patients, showing that elevated FC levels were linked to poorer clinical responses and worse long-term outcomes, including complications and mortality.
- * Results indicated that high FC levels are more common in complicated cases of CD and NCEs, suggesting that FC could be a useful marker for assessing disease severity and predicting future health issues.
Background: Data on resilience, the ability to recover from adversity, in coeliac disease (CeD) are lacking.
Aim: To assess the degree of resilience in patients with CeD on a gluten-free diet (GFD), and its association with clinical features, sociodemographic factors, psychological morbidity, and quality of life (QOL).
Methods: A cross-sectional multicentre Italian study was conducted on adult CeD patients between May 2022 and April 2023.
A small bowel adenocarcinoma harboring a DDR2 mutation in a celiac patient.
Clin J Gastroenterol
December 2024
Article Synopsis
- A 62-year-old man with celiac disease went to the hospital because he had stomach pain, tiredness, and bleeding in his stool.
- Doctors checked his insides with cameras and found a bad growth in his small intestine.
- After surgery to remove the bad part, they discovered he had cancer but used special testing that showed some gene changes, which might help find better treatments in the future.
Distinguishing Features of Autoimmune Gastritis Depending on Previous Helicobacter pylori Infection or Positivity to Anti-Parietal Cell Antibodies: Results From the Autoimmune gastRitis Italian netwOrk Study grOup (ARIOSO).
Am J Gastroenterol
December 2024
Article Synopsis
- The study aimed to analyze the clinical characteristics and gastric tumor risk in patients with autoimmune gastritis (AIG) across eight Italian hospitals, focusing on those with and without Helicobacter pylori infection.
- A total of 1,598 AIG patients were assessed; findings indicated that those who were H. pylori-naive had a higher tendency for certain autoimmune conditions and significant family health history.
- The overall incidence of gastric adenocarcinoma was low, but a notable percentage developed type 1 gastric neuroendocrine neoplasm (gNEN), especially in patients presenting with vitamin B12/iron deficiencies, suggesting these individuals should receive closer monitoring.
Comparison between SeHCAT test and clinical response to cholestyramine in patients with chronic diarrhea and high suspicion of bile acid malabsorption: A single-center prospective study.
J Dig Dis
May 2024
Objectives: We aimed to evaluate the clinical response to cholestyramine in patients with functional chronic diarrhea and a high clinical suspicion of bile-acid diarrhea (BAD) investigated with 75-selenium homocholic acid taurine (SeHCAT) test.
Methods: Adult patients attending our outpatient clinic between January and December 2021 for chronic diarrhea with suspicion of BAD were proposed SeHCAT testing and a therapeutic trial of cholestyramine 4-8 g daily. Clinical response to cholestyramine was evaluated at 1, 3, 6, and 12 months.
Superior bowel preparation quality for colonoscopy with 1L-PEG compared to 2L-PEG and picosulphate: Data from a large real-world retrospective outpatient cohort.
Dig Liver Dis
November 2024
Article Synopsis
- Several clinical trials have shown that different bowel preparations (BPs) work similarly, but there's a lack of real-world studies comparing them.
- This study, conducted over 14 months with 1,779 patients at an academic hospital, focused on the effectiveness of 1L-PEG compared to 2L-PEG and picosulphate mixtures in achieving proper bowel preparation before colonoscopy.
- The findings reveal that 1L-PEG significantly improves bowel preparation adequacy and identifies specific risk factors, like male sex and smoking, that lead to inadequate preparation, suggesting it enhances clinical practice and saves healthcare resources.
Article Synopsis
- Persistent symptoms in coeliac disease (CD) may result from non-adherence to a gluten-free diet (GFD), CD complications, or functional disorders like irritable bowel syndrome (IBS).
- A systematic review of literature identified six studies examining the effects of a low-FODMAP diet for coeliac patients experiencing IBS-like symptoms despite GFD adherence, finding significant symptoms reduction with a low-FODMAP GFD.
- Although GFDs generally have lower FODMAP contents than regular diets, coeliac patients tended to consume more high-FODMAP fruits and vegetables without a clear link between FODMAP intake and persistent symptoms.
Background: Ultra-short coeliac disease (USCD) is defined as villous atrophy only present in the duodenal bulb (D1) with concurrent positive coeliac serology. We present the first, multicentre, international study of patients with USCD.
Methods: Patients with USCD were identified from 10 tertiary hospitals (6 from Europe, 2 from Asia, 1 from North America and 1 from Australasia) and compared with age-matched and sex-matched patients with conventional coeliac disease.
Article Synopsis
- - The study systematically reviewed various research articles to analyze all-cause and cause-specific mortality rates in individuals with coeliac disease compared to the general population, revealing that mortality rates were generally higher, especially due to malignancies like non-Hodgkin lymphoma.
- - Findings indicated that although all-cause mortality was elevated, recent decades have shown a significant decrease in mortality rates, with a notable difference observed between clinical phenotypes and geographical regions.
- - Limitations of the study include high variability in the data and insufficient information from multiple countries, but the results emphasize the importance of understanding mortality trends in coeliac disease for better diagnosis and management.
Background: Although enteropathy due to angiotensin II receptor blockers (ARBs) has been known for over 10 years, clinicians' awareness of this condition is still low.
Aims: To systematically review the literature about clinical phenotypes, distribution of mucosal changes throughout the gastrointestinal tract and prognosis of enteropathy due to ARBs.
Methods: According to PRISMA guidelines, we searched PubMed and Embase for relevant articles up to November 6, 2023.