Sex-specific disparities in clinical characteristics and outcomes of catheter-directed treatments for acute pulmonary embolism.

Background: Acute pulmonary embolism (PE) represents a cardiovascular emergency with increasing incidence. Catheter-directed treatments (CDTs) are increasingly used for high-risk or intermediate-high-risk PE patients when surgical embolectomy or systemic thrombolysis (ST) is contraindicated or ineffective. Although prior research suggests poorer outcomes in women with PE, sex-specific differences in CDTs outcomes remain unclear.

Role of Transcatheter Treatment in Intermediate-to High-risk Pulmonary Embolism.

Pulmonary embolism (PE) is the third major cause of cardiovascular death in western countries. High-risk PE, defined by haemodynamic instability, necessitates immediate reperfusion therapy. Intermediate-high-risk patients, although stable, are vulnerable to rapid deterioration and therefore require intensive monitoring.

The role of Pulmonary Artery Pulsatility Index to assess the outcomes following catheter directed therapy in patients with intermediate-to-high and high-risk pulmonary embolism.

Background: The clinical impact of catheter-directed therapy (CDT) for pulmonary embolism (PE) on right ventricular function and procedural outcomes remains undefined.

Methods: This observational retrospective study included consecutive patients who underwent CDT for PE at San Giovanni Bosco Hospital, Italy, and First Department of Cardiology, Poznan University Clinical Hospital, Poland, between 2021 and 2023. Clinical characteristics, PE risk stratification, pre and post-interventional invasive pulmonary artery pressure (PAP), and Pulmonary Artery Pulsatility Index (PAPi) were collected.

Polyethylene Glycol microspheres for uterine artery embolization for the treatment of symptomatic uterine fibroids.

Background: Uterine fibroids are prevalent benign pelvic tumors, often causing debilitating symptoms that impair quality of life. Uterine fibroid embolization (UFE) is a consolidated minimally invasive treatment option. The purpose of this study is to report our experience with polyethylene glycol microspheres (HydroPearl) in UFE for symptomatic patients.

Improvement of anthropometric and metabolic parameters, and quality of life following treatment with dual-release hydrocortisone in patients with Addison's disease.

In patients with Addison's disease (AD), a dual-release preparation of hydrocortisone (Plenadren, PLEN) has been demonstrated to maintain cortisol levels in a more physiological range than conventional glucocorticoid therapy, and to exert positive effects. This study aimed to assess variations of anthropometric, metabolic, and hormonal parameters in patients with AD after switching from conventional hydrocortisone (HC) treatment to PLEN. In nineteen AD patients (15 F and 4 M, age 27-65 years) treated with HC 20 mg/day thrice daily, body weight, BMI, waist circumference, fasting glucose, HbA1c, serum lipids, plasma renin activity, electrolytes, and blood pressure were evaluated at baseline, and 1, 3, 6, and 12 months after switching from HC to PLEN.