Publications by authors named "Federica Barbugian"
Glioblastoma multiforme (GBM) is an extremely malignant cancer, resistant to standard therapies. Tumor resection is associated with better outcomes but a complete resection of GBMs is challenging for anatomical limitation and for the high degree of invasiveness. A bioresponsive hydrogel based on hyaluronic acid (HA) cross-linked with a branched metalloproteinase (MMP) inhibitor (MMPI) is proposed.
View Article and Find Full Text PDFCell microenvironment contains a plethora of information that influences cell modulation. Indeed, the extracellular matrix plays a central role in tissue development. Reproducing the cell-extracellular matrix crosstalk able to recapitulate both physical and biochemical signals is crucial to obtain functional tissue models or regenerative strategies.
View Article and Find Full Text PDFArticle Synopsis
- * The study introduces a new delivery system using 150-nm liposomes to enhance the effectiveness of Givinostat, a pan-HDAC inhibitor, by improving its half-life in the bloodstream and increasing its delivery to the brain.
- * In vitro and in vivo results showed that these liposome-Givinostat formulations effectively inhibited glioblastoma cell growth and enhanced drug delivery without causing noticeable toxicity, suggesting they hold promise for future glioblastoma therapies.