Publications by authors named "Farokh R Demehri"

Introduction: The use of cotton sponges in the operating room has been linked to intraperitoneal adhesion formation. Inert, nonlinting polyvinyl alcohol (PVA) sponges have been used as an alternative to reduce intraoperative tissue trauma and particle remnants in other surgical fields. We investigate the effect of PVA sponges on reducing postoperative intraperitoneal adhesions in a murine model.

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Introduction: Pectus excavatum (PE) is the most common congenital chest wall deformity. The vacuum bell (VB) is a nonoperative alternative to surgical correction. We reviewed our center's experience with VB for PE to identify variables associated with improved therapeutic success, with a focus on compliance to prescribed VB therapy.

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Background And Objective: Pectus excavatum is a common congenital chest wall abnormality characterized by a concave appearance of the chest, and minimally invasive repair of pectus excavatum (MIRPE) is the surgical treatment of choice. A rapidly growing field of research is pain management in children undergoing MIRPE, with many shifts in practice occurring over the last decade. The primary objectives of this narrative review are to describe current methods of perioperative pain management and the development of enhanced recovery after surgery (ERAS) to improve the experience of patients undergoing MIRPE.

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Article Synopsis
  • The study aimed to measure mediastinal positioning in neonates with congenital diaphragmatic hernia (CDH) using chest x-rays, particularly in those needing extracorporeal membrane oxygenation (ECMO).
  • Researchers developed a Mediastinal Shift Index (MSI) to quantitatively assess mediastinal shift and found it had excellent agreement among different raters.
  • Results indicated that a higher initial MSI was significantly associated with survival, demonstrating stronger predictive value compared to the observed/expected lung head ratio (O/E LHR).
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Objective: To investigate the effectiveness of intraoperative nerve monitoring at decreasing vocal fold movement impairment in children undergoing at-risk procedures.

Background: Children undergoing aerodigestive or cardiovascular procedures are at risk for recurrent laryngeal nerve injury, leading to vocal fold movement impairment. Although intraoperative nerve monitoring has been shown to decrease recurrent laryngeal nerve injury in adults, there is paucity of data in children.

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  • The study aimed to evaluate how surgical management varies for pediatric patients with Congenital Diaphragmatic Hernia (CDH) who also have other health complications that might require surgery.
  • Researchers analyzed data from children who had CDH repair between 2012 and 2022, focusing on how often they needed additional surgeries like gastrostomy or tracheostomy following their initial treatment.
  • Results showed that nearly half of the patients required further surgical interventions, with significant regional differences in practices and higher costs and hospital stays linked to these additional procedures.
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Background: The management of neonates with long-gap esophageal atresia (LGEA) combined with distal congenital esophageal strictures (CES) is challenging. We sought to review our approach for this rare set of anomalies.

Methods: We reviewed children with LGEA + CES surgically treated at two institutions (2018-2024).

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Background: The traction-induced esophageal growth (Foker) process for the treatment of long gap esophageal atresia (LGEA) relies on applying progressive tension to the esophagus to induce growth. Due to its anti-fibrotic and muscle-relaxing properties, we hypothesize that Botulinum Toxin A (BTX) can enhance traction-induced esophageal growth.

Methods: A retrospective two-center cohort study was conducted on children who underwent a BTX-enhanced Foker process for LGEA repair from 2021 to 2023.

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Transplantation of non-US citizen residents remains controversial. We evaluate national trends in transplant activity among pediatric noncitizen residents (PNCR). Pediatric liver and kidney transplant data were obtained from the Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients.

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Objectives: Our study examines if the disease severity profile of our Congenital Diaphragmatic Hernia (CDH) patient cohort adherent to long-term follow-up differs from patients lost to follow-up after discharge and examines factors associated with health care utilization.

Methods: Retrospective review identified CDH survivors born 2005-2019 with index repair at our institution. Primary outcome was long-term follow-up status: "active" or "inactive" according to clinic guidelines.

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  • Tracheobronchomalacia (TBM) leads to severe airway collapse and can cause serious health issues, especially in children, with this study focusing on those with severe primary TBM without underlying causes like esophageal atresia or vascular issues.
  • A cohort of 73 children underwent airway pexy surgery, and the study compared their symptoms and bronchoscopic findings before and after the procedure.
  • Results showed significant improvements in many symptoms, but about 29% of patients still had issues afterward, leading to further surgical interventions for symptom relief.
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Purpose: Topical ice has been shown to reduce pain scores and opioid use in adults with midline abdominal incisions. This study was designed to evaluate the efficacy of a cold therapy system in children following laparoscopic appendectomy.

Methods: Patients 7 years and older who underwent laparoscopic appendectomy at our institution from December 2021-September 2022 were eligible.

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Article Synopsis
  • In the past, kids with a serious condition called long gap esophageal atresia (LGEA) had limited treatment options and often relied on feeding through a tube.
  • In 1997, a doctor named John Foker created a new method to help these kids grow their own esophagus using a special system that stretched it over time.
  • This new approach faced some skepticism, but it helped start a movement towards better care for children with esophageal issues, leading to the creation of specialized treatment centers and new medical techniques.
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Purpose: In neonates with suspected type C esophageal atresia and tracheoesophageal fistula (EA/TEF) who require preoperative intubation, some texts advocate for attempted "deep" or distal-to-fistula intubation. However, this can lead to gastric distension and ventilatory compromise if a distal fistula is accidently intubated. This study examines the distribution of tracheoesophageal fistula locations in neonates with type C EA/TEF as determined by intraoperative bronchoscopy.

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Purpose: Esophageal atresia with tracheoesophageal fistula (EA/TEF) is often associated with tracheobronchomalacia (TBM), which contributes to respiratory morbidity. Posterior tracheopexy (PT) is an established technique to treat TBM that develops after EA/TEF repair. This study evaluates the impact of primary PT at the time of initial EA/TEF repair.

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Purpose: Abnormalities in notochordal development can cause a range of developmental malformations, including the split notochord syndrome and split cord malformations. We describe two cases that appear related to unusual notochordal malformations, in a female and a male infant diagnosed in the early postnatal and prenatal periods, which were treated at our institution. These cases were unusual from prior cases given a shared constellation of an anterior cervicothoracic meningocele with a prominent "neural stalk," which coursed ventrally from the spinal cord into the thorax in proximity to a foregut duplication cyst.

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Background: Anastomotic strictures (AS) after esophageal atresia (EA) repair are common. While most respond to endoscopic therapy, some become refractory and require surgical intervention, for which the outcomes are not well established.

Methods: All EA children with AS who were treated surgically at two institutions (2011-2022) were retrospectively reviewed.

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  • Pediatric surgery applicants are increasingly engaging in research related to surgical innovation, and this study assesses how pediatric surgeons value this experience compared to traditional research metrics.
  • A survey of pediatric surgeons revealed that a significant majority believe innovation experience is as valuable, or even more so, than traditional research in certain contexts, despite some concerns about the lack of publications and potential financial motivations.
  • While innovation experience is generally regarded positively, candidates are advised to also focus on traditional academic achievements to enhance their competitiveness in fellowship selection.
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Background: Laparoscopic gastrostomy is commonly performed for durable enteral access in children. T-fasteners have been used intraoperatively to achieve a secure gastropexy, traditionally using external bolsters. We compare the safety profile of a modified paired T-fastener technique to standard laparoscopic-assisted suture gastropexy.

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  • Children undergoing cervical and thoracic surgeries are at a high risk of recurrent laryngeal nerve injury, which can lead to vocal fold movement impairment (VFMI).
  • A study conducted from 2017 to 2021 analyzed 297 patients, revealing that 24% had VFMI, and notably, almost half of those did not show common symptoms.
  • The findings suggest that all at-risk patients should be routinely screened for VFMI, especially those with a history of relevant surgeries or specific medical devices like tracheostomies or feeding tubes.
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Background And Objective: Pectus excavatum is the most common congenital chest wall anomaly, the hallmark of which is the caved-in appearance of the anterior chest. A growing body of literature exists surrounding methods of surgical correction, though considerable variability in management remains. The primary objectives of this review are to outline the current practices surrounding the care of pediatric patients with pectus excavatum and present emerging trends in the field that continue to impact the care of these patients.

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Purpose: The purpose of this study was to analyze the management and outcomes of primary button battery ingestions and their sequelae at a single high-volume center, and to propose a risk score to predict the likelihood of a severe outcome.

Methods: The medical record was queried for all patients under 21 years old evaluated at our institution for button battery ingestion from 2008 to 2021. A severe outcome was defined as having at least one of the following: deep/circumferential mucosal erosion, perforation, mediastinitis, vascular or airway injury/fistula, or development of esophageal stricture.

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 The congenital anomaly of omphalocele, cloacal exstrophy, imperforate anus, and spinal abnormalities (OEIS complex) is rare but well recognized. Hindgut duplications are also uncommon and are not known to be associated with OEIS. We describe a neonate with OEIS who was found to have fully duplicated blind-ending hindguts.

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Congenital anorectal malformations are generally diagnosed and repaired as a neonate or infant, but repair is sometimes delayed. Considerations for operative repair change as the patient approaches full stature. We recently encountered a 17-year-old male with an unrepaired congenital rectourethral fistula and detail our experience with his repair.

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