Upscaling, toxicity and efficacy of multifaceted dressing embedded with dsirna-loaded gold nanoparticles for enhancing diabetic wound treatment.

Poor vascularization and infections hinder diabetic wound healing, posing challenges in therapy development. A multi-action approach incorporating Dicer-substrate small interfering RNA (DsiRNA) against the prostaglandin transporter (PGT) gene and gold nanoparticles (AuNPs) into a Pluronic F-127 (PF127) gel was developed. This study aimed to upscale AuNP biosynthesis using Lignosus rhinocerotis (tiger milk mushroom, TMM) extract and chitosan as stabilizers.

Potential Hemostatic and Wound Healing Effects of Thermoresponsive Wound Dressing Gel Loaded with and Extracts.

Biologically active compounds in and are found to facilitate wound healing and exhibit hemostatic activity, making them a good combination as bioactives for wound dressings. This study, therefore, aimed to evaluate the potential of thermoresponsive gels loaded with (HLRE) and (PPE) extracts as dressings for wound treatment. The gels were prepared using Pluronic PF127 polymer and mixed with PEG 400 and/or starch prior to incorporation with both extracts (0.

Roles of chitosan in synthesis, antibacterial and anti-biofilm properties of bionano silver and gold.

Antibiotic-resistance and bacterial bioburden on wound surfaces are the significant challenges to wound healing. Silver and gold nanoparticles (are termed as AgNPs and AuNPs) have been investigated as alternative antimicrobial agents to combat antibiotic-resistant bacterial infections owing to their antibacterial and anti-biofilm activities. Chitosan (CS) has largely been used in nanoparticle synthesis as a stabilizing or capping agent.