Publications by authors named "Fanny Dor"
Temporal and spatial heterogeneity of HER2 status in metastatic colorectal cancer.
Diagn Pathol
June 2024
Background: HER2-targeted therapies have recently emerged as an option in the management of metastatic colorectal cancer (mCRC) overexpressing HER2. However, data regarding HER2 status in primary CRC and its corresponding liver metastases are limited, potentially influencing clinical decisions. Therefore, the aim of this study was to compare the HER2 status in primary CRC and paired liver metastases.
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- The study investigates the "gray-zone" of HPV test results in cervical cancer screening, where test sensitivity and clinical thresholds vary.
- Over a 22-month period, 1.7% of HPV results from over 6,100 samples fell into this gray-zone, with higher prevalence in certain HPV genotypes.
- Most gray-zone results showed no significant cytological abnormalities, but a small number of patients with a history of persistent HPV should be monitored closely due to potential risks.
Background And Aims: In colorectal cancer (CRC), HER2 targeting is a promising treatment and immune infiltrate is an important area of research and strategy. Data regarding HER2 status and immune infiltrate are lacking. The aim of this study was to compare the immune infiltrate between HER2 amplified and non-amplified categories in proficient MisMatchRepair (pMMR)/microsatellite stable (MSS) CRC.
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