Spatial protein redistribution: wandering but not lost.

Interorganellar spatial redistribution of proteins represents a critical yet underexplored facet of eukaryotic cell biology. This dynamic aspect of proteostasis allows proteins to acquire novel functions based on their subcellular localization, enabling the cell to adapt to both physiological and pathological challenges. Such spatial reprogramming is especially pronounced under stress conditions, including those associated with cancer, neurodegenerative diseases and viral infection, where widespread remodeling of the proteome facilitates survival and adaptation.