Publications by authors named "Fabrizio Zullo"

Background: Adverse neonatal and maternal outcomes are understudied for parturients with diabetes who deliver macrosomic newborns.

Objective: We hypothesized that composite-neonatal (CNAO) and maternal adverse outcomes (CMAO) would be significantly higher for individuals with diabetes macrosomic newborns.

Study Design: This was a secondary analysis of APEX cohorts.

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Objective: To evaluate the effectiveness of antenatal corticosteroid administration in the late preterm period (34 0/7-36 6/7 weeks of gestation).

Data Sources: A Medical Librarian performed a search in the following databases and grey literature sources from inception until July 15, 2024: PubMed (NLM), Embase.com (Elsevier), Scopus (Elsevier), Cochrane CENTRAL (Wiley), CINAHL Ultimate (EBSCOHost), ClinicalTrials.

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The primary objective was to ascertain if the proportion of time in category II fetal heart rate tracing (FHRT) prior to birth among term (≥ 37 weeks) singletons in labor was associated with composite adverse neonatal outcomes (CANO).The inclusion criteria for this retrospective cohort study were nonanomalous singletons at term, whose FHRT was reviewed by obstetricians blinded to the maternal characteristics and neonatal outcomes. According to ACOG's criteria, the last 20 to 120 minutes of the tracing were reviewed in 20-minute epochs.

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Most shoulder dystocia (SD) cases do not have associated adverse outcomes. The objective was to assess whether SD relieved with ≥3 maneuvers, compared with fewer, is associated with a higher likelihood of adverse outcomes. The secondary objective was to examine if postpartum hemorrhage is associated with SD managed with ≥3 maneuvers versus fewer.

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Objectives: To assess the efficacy of remote blood pressure monitoring to prevent readmission due to complications of hypertensive disorders of pregnancy.

Methods: The search was conducted using MEDLINE, EMBASE, Web-of-Sciences, Scopus, ClinicalTrial.gov, OVID and Cochrane-Library as electronic databases from the inception of each database to November 2023.

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Objective: To compare the effectiveness of administering 24 mg of betamethasone in two doses (12 mg each) at 12-hour versus 24-hour intervals in patients at risk of preterm delivery.

Data Sources: A search was conducted in Ovid, Embase, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, CINAHL, Scopus, and Google Scholar up to February 22, 2023.

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Objective: This study aimed to assess whether high- vs low-dose oxytocin regimens for labor augmentation are associated with differential risk of low Apgar score, neonatal acidosis, and other adverse labor outcomes.

Data Sources: We searched electronic databases (MEDLINE, Embase, the Cochrane Library, CINAHL, Scopus, ClinicalTrials.gov) from inception up to March 2024 using combinations of the following key words: "oxytocin," "oxytocin regimen," "oxytocin protocol," "oxytocin dosage," "active management," "high dose protocol," "low dose protocol," and "augmentation of labor.

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Twin pregnancies account for 3% of all pregnancies and they are burdened by higher morbidity and mortality compared to singletons. The role of ultrasound in the screening, diagnosis and management of possible complications of twin pregnancies has been widely investigated in the current literature. However, despite the progress that have been made in the last decades regarding treatment and evidence-based management of complications, twin pregnancies remain at higher risk of adverse outcomes, requiring therefore dedicated surveillance.

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Twin pregnancies are at increased risk of morbidity and mortality compared to singletons. Among all twins, monochorionic pregnancies are at higher risk of specific and non-specific complications compared to dichorionic pregnancies. Therefore, it is of great importance to properly counsel future parents with monochorionic pregnancies regarding the risks of adverse outcomes and the modalities of monitoring and intervention of the potential complications.

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Cervical cerclage is a widely used intervention to prevent preterm birth in high-risk pregnancies. However, cerclage is associate with risks, including preterm premature rupture of membranes and subsequent complications, such as chorioamnionitis. Our review evaluates the evidence for immediate removal (ie, removal at the time of diagnosis) vs retention of cervical cerclage (ie, removal when clinically indicated) after preterm premature rupture of membranes, focusing on optimizing neonatal outcomes and minimizing maternal and fetal complications.

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Article Synopsis
  • - This study aimed to evaluate how much pregnant women and hospital staff know about umbilical cord blood (UCB) donation and storage, revealing key insights into their views and practices.
  • - A total of 19 studies involving nearly 20,000 pregnant women and over 1,200 hospital staff showed that awareness of UCB was 61% for both groups, with 57% of pregnant women having a positive attitude toward UCB donation.
  • - The findings indicated a strong preference for public UCB banking over private options, with 51% of pregnant women favoring public storage compared to only 12% for private storage.
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Objective: To investigate the rate of obstetric and perinatal outcomes of premature rupture of membranes (PROM) occurring before 26 weeks in twin pregnancies.

Data Source: Medline, Embase, Cinahl and Web of Science databases were searched electronically up to January 2024.

Study Eligibility Criteria: The selection criteria included both prospective and retrospective studies of twin pregnancies with PROM before 26 weeks of gestation.

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Background: As resources into gynecological surgical simulation training increase, research showing an association with improved clinical outcomes is needed.

Objective: To evaluate the association between surgical simulation training for total laparoscopic hysterectomy (TLH) and rates of intraoperative vascular/visceral injury (primary outcome) and operative time.

Search Strategy: We searched Medline OVID, Embase, Web of Science, Cochrane, and CINAHL databases from the inception of each database to April 5, 2022.

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Objective: Counseling of pregnancies complicated by pre- and periviable premature rupture of membranes to reach shared decision-making is challenging, and the current limited evidence hampers the robustness of the information provided. This study aimed to elucidate the rate of obstetrical and neonatal outcomes after expectant management for premature rupture of membranes occurring before or at the limit of viability.

Data Sources: Medline, Embase, CINAHL, and Web of Science databases were searched electronically up to September 2023.

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Although the clinical work-up of CMV in pregnancy has gradually become more accurate, counseling for CMV is still challenging. Despite the potential feasibility of universal prenatal serological screening, its introduction in prenatal diagnosis continues to raise concerns related to its real cost-effectiveness. Contextually, anticipating the confirmation of fetal infection earlier in pregnancy is one of the most pressing issues to reduce the parental psychological burden.

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Objective: To evaluate maternal and perinatal outcomes of removal versus retention of cervical cerclage after premature preterm rupture of membranes (pPROM).

Study Design: Medline, Embase and Cochrane databases were searched electronically on February 2023 utilizing combinations of the relevant medical subject heading (MeSH) terms, keywords, and word variants that were considered suitable for the topic. Either prospective or retrospective trials were considered suitable for the inclusion.

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In the setting of postpartum care after vaginal delivery, rooming-in is associated with a higher rate of exclusive breastfeeding rate at hospital discharge, but there is insufficient evidence to support or refute rooming-in to increase breastfeeding at 6 months. Education and support for breastfeeding are valuable interventions to promote initiation of breastfeeding whether it is offered by a healthcare professional, nonhealthcare professional, or peer. A combined intervention, a professional provider-led intervention, having a protocol available for the provider training program, and implementation during both the prenatal and postnatal periods increased the rate of exclusive breastfeeding for 6 months.

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Objective: This study aimed to evaluate the rate of adverse neonatal or maternal outcomes in parturients with fetal heart rate tracings categorized as I, II or, III within the last 30 to 120 minutes of delivery.

Data Sources: The MEDLINE Ovid, Scopus, Embase, CINAHL, and Clinicaltrials.gov databases were searched electronically up to May 2022, using combinations of the relevant medical subject heading terms, keywords, and word variants that were considered suitable for the topic.

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Article Synopsis
  • * Electron microscopy confirmed the presence of SARS-CoV-2 particles in the placenta, particularly affecting the fetal capillaries and causing vascular issues.
  • * This case highlights the risk of stillbirth linked to COVID-19 infections via effects on placental blood flow, which may not be detected through routine clinical checks.
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