Early-onset growth hormone treatment in Prader-Willi syndrome attenuates transition to severe obesity.

Objectives: Subsequent to early life feeding issues, children with Prader-Willi syndrome (PWS) develop hyperphagia and severe obesity. Growth hormone (GH) therapy has been approved in PWS to improve growth, body composition, and BMI. We aimed to clarify the role of age at GH therapy onset on growth and BMI trajectories in children with PWS.

Prevalence of iodine deficiency among vegan compared to vegetarian and omnivore children in the Czech Republic: cross-sectional study.

Background: The intake and homeostasis of iodine, an essential micronutrient that plays a vital role in thyroid physiology, is of particular concern with the increasing popularity of vegetarian (VG) and vegan (VN) diets. Children on these restrictive diets may be at risk of possible adverse effects on growth and development, but there is currently a lack of recent epidemiological studies on this topic.

Methods: We gathered clinical, anthropometric, and blood/urine data on iodine status and thyroid function from children aged 0-18 years who followed either a VG diet (n = 91), VN diet (n = 75), or omnivore diet (OM, n = 52).

Cross-Sectional Study of the Prevalence of Cobalamin Deficiency and Vitamin B12 Supplementation Habits among Vegetarian and Vegan Children in the Czech Republic.

Vegetarian (VG) and vegan (VN) diets in childhood are of growing interest due to their perceived health and environmental benefits. Concerns remain due to the possible disruption of healthy growth and development of children because of the scarcity of evidence-based studies. Among the nutrients of special concern is vitamin B12.

Problematics of iodine saturation among children on the vegan diet.

Plant-based diets, which includes veganism, is now rapidly gaining popularity. In the absence of the knowledge how to provide all the risky nutrients, this style of eating can lead to nutritional deficits that result in disruption of the physiological development of the child. One of the risk elements also includes iodine.

Problematics of iodine saturation among children on the vegan diet.

Plant-based diets, which includes veganism, is now rapidly gaining popularity. In the absence of the knowledge how to provide all the risky nutrients, this style of eating can lead to nutritional deficits that result in disruption of the physiological development of the child. One of the risk elements also includes iodine.

Iodine intake monitoring in neonatal population in the Czech Republic: alarming numbers in 2020.

Thanks to comprehensive and long-term preventive programs, the Czech Republic has taken its place among the countries with a resolved iodine deficiency at all population levels since 2004. A sensitive indicator of iodine supply to the population, which can also be used to monitor the efficiency of prophylactic programs, is the TSH assessment in the nationwide neonatal screening of congenital hypothyroidism. Nevertheless, recent results of neonatal TSH show that newborns and pregnant women remain very risky groups and their iodine saturation is borderline.

Novel presentation of the c.1856A > G (p.Asp619Gly) TSHR gene-activating variant: relapsing hyperthyroidism in three subsequent generations manifesting in early childhood and an in vitro functional study.

Background: Familial non-autoimmune hyperthyroidism is a rare disease caused by germline activating variants in the thyroid-stimulating hormone receptor (TSHR) gene. The c.1856A > G (p.