Identification of Biosynthetic Precursors and Optimization of 7-Hydroxytropolone Bioproduction by PA14H7.

Cell-free supernatant of the strain PA14H7 has previously shown interesting activity against Soft Rot (SRP), the bacterial pathogen responsible for blackleg and soft rot diseases in potatoes. A deeper understanding of its mode of action is essential to optimize its use as a biocontrol agent. We previously reported that PA14H7 produces a specialized metabolite, the 7-hydroxytropolone (7-HT), which acts as an iron chelator, limiting the growth of SRP.

PA14H7: Identification and Quantification of the 7-Hydroxytropolone Iron Complex as an Active Metabolite against , the Causal Agent of Blackleg on the Potato Plant.

Soft rot (SRP), such as and , are phytopathogenic agents responsible for blackleg disease on several crops, such as potatoes, affecting the yield and depressing the seed production quality. However, neither conventional nor biocontrol products are available on the market to control this disease. In this study PA14H7, a bacteria isolated from potato rhizosphere, was selected as a potential antagonist agent against .