Publications by authors named "Eun-Bin Hong"
Phospholipase C (PLC) enzymes play crucial roles in intracellular calcium-signaling transduction. Several brain PLC subtypes have been extensively studied, implicating them in psychiatric disorders such as depression, epilepsy and schizophrenia. However, the role of the recently identified PLCη remains largely unknown.
View Article and Find Full Text PDFArticle Synopsis
- - Neuropathic pain results from hyperactive spinal dorsal horn neurons, leading to symptoms like allodynia, and the role of astrocyte-neuron interactions is not fully understood.
- - Research found that reactive astrocytes release excessive GABA, which unexpectedly excites nearby neurons due to altered GABA processing mechanisms, linking astrocytic activity to increased neuronal hyperexcitability.
- - Inhibiting monoamine oxidase B (MAOB) can reverse these changes, restoring normal GABA function, reducing glucose metabolism in the dorsal horn, and alleviating allodynia, suggesting that astrocytic GABA plays a crucial role in neuropathic pain.
Aims: γ-aminobutyric acid (GABA) from reactive astrocytes is critical for the dysregulation of neuronal activity in various neuroinflammatory conditions. While Scutellaria baicalensis Georgi (S. baicalensis) is known for its efficacy in addressing neurological symptoms, its potential to reduce GABA synthesis in reactive astrocytes and the associated neuronal suppression remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- Bioresorbable neural implants made from biodegradable materials aim to eliminate the need for secondary surgeries to remove traditional devices.
- The study showcases a flexible opto-electronic system that allows for both electrophysiological recording and optogenetic stimulation, designed to work well with the brain's surface.
- The research demonstrates successful long-term implantation in mice, offering a potential dual-function tool for monitoring and therapy in biomedical applications.