Publications by authors named "Eugene Chen Howe Goh"
Novel Oxidative Stress Biomarkers with Risk Prognosis Values in Heart Failure.
Biomedicines
March 2023
Oxidative stress (OS) is mediated by reactive oxygen species (ROS), which in cardiovascular and other disease states, damage DNA, lipids, proteins, other cellular and extra-cellular components. OS is both initiated by, and triggers inflammation, cardiomyocyte apoptosis, matrix remodeling, myocardial fibrosis, and neurohumoral activation. These have been linked to the development of heart failure (HF).
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- The study investigates oxidative stress markers in emergency department (ED) patients to predict hospital and ICU length of stay and sepsis severity.
- Out of 290 patients, homoarginine (hArg) was identified as the most significant marker for differentiating sepsis severity, strongly correlating with longer hospital and ICU stays.
- The findings suggest that hArg can improve clinical predictions for treatment decisions in ED patients experiencing sepsis, outperforming other related metabolic markers.
Background: There is limited data on the mechanisms of aspirin desensitization in patients with nonsteroidal anti-inflammatory drug (NSAID)-induced urticaria/angioedema (NIUA).
Objectives: We sought to characterize the transcriptomic and metabolomic profiles of patients with NIUA undergoing aspirin desensitization.
Methods: PBMCs and plasma were separated from the blood of patients with NIUA undergoing aspirin desensitization for coronary artery disease and NSAID-tolerant controls.