Predicting Primary Graft Dysfunction in Systemic Sclerosis Lung Transplantation Using Machine-Learning and CT Features.

Introduction: Primary graft dysfunction (PGD) is a significant barrier to survival in lung transplant (LTx) recipients. PGD in patients with systemic sclerosis (SSc) remains especially underrepresented in research.

Methods: We investigated 92 SSc recipients (mean age 51 years ± 10) who underwent bilateral LTx between 2007 and 2020.

The length of the warm ischemic interval in lung donation after circulatory death does not impact post-transplantation outcomes.

Introduction: Transplantation of lungs obtained by donation after circulatory death (DCD) has increased the number of available organs. This study aims to determine how donor characteristics and current procurement processes (specifically, agonal and warm ischemic times) influence the outcomes experienced by the recipients of DCD lung transplants.

Materials And Methods: An analysis was conducted on United Network for Organ Sharing data collected from January 2018 to June 30, 2024, with a focus on adult recipients of double lung transplants with a DCD donor.

Outcomes of lung transplantation for scleroderma versus other indications: Insigts from a single center.

Background: Scleroderma is an autoimmune disease affecting the skin and internal organs, with pulmonary disease being the leading cause of mortality. Lung transplantation is a potential therapy, but its indication has been limited by concerns about complications, such as esophageal dysmotility.

Methods: A retrospective analysis was performed on 959 lung transplant patients from 2011 to 2023, including 77 with scleroderma-related lung disease.

Extracorporeal membrane oxygenation after lung transplant: An ELSO registry analysis.

BackgroundThe use of extracorporeal membrane oxygenation (ECMO) has expanded and is now widely applied to perioperative care in lung transplant. Respiratory failure after lung transplant is a clinical challenge where ECMO plays a critical role.MethodsThe Extracorporeal Life Support Organization registry was queried for patients 18 years and older who were treated with ECMO after lung transplant in 2010-2022.

The Relationship Between Ex Vivo Lung Perfusion Strategies and Transplantation Outcomes: Insights From the United Network for Organ Sharing Data.

Background: Ex vivo lung perfusion (EVLP) can increase the donor pool by allowing high-risk lungs to be further evaluated for transplant. Several EVLP platforms are currently in use. This study examines whether different EVLP platforms have any association with post-transplant outcomes.

Extracorporeal Membranous Oxygenation Associated With Tracheal Procedures: An Extracorporeal Life Support Organization (ELSO) Registry Analysis.

Extracorporeal membrane oxygenation (ECMO) has been primarily used for respiratory and circulatory failure, but its airway-related use has not been investigated well. Tracheal procedures are a situation when ECMO could be used to support patients during anticipated difficult airway management. The Extracorporeal Life Support Organization registry was queried for adult patients treated with ECMO in 2010-2022 during the same admission with types of tracheal procedures.

CT-Based Lung Size Matching in Delayed Chest Closure for Systemic Sclerosis Lung Transplantation.

Purpose: Delayed chest closure (DCC) during lung transplantation (LTx) is a controversial surgical approach that lacks research in systemic sclerosis (SSc) patients. We investigated outcomes, clinical risk factors, and CT-based lung size-matching parameters associated with DCC in SSc recipients.

Methods: This retrospective study included 92 SSc recipients (age 51 years ± 10, 56/92 (61.

Adoption of a semi-elective lung transplantation practice by safely extending cold ischemic times.

Objective: Lung transplantation is a complex surgical procedure performed by specialized teams. Practice changes to eliminate overnight lung transplants were implemented at our center and patient outcomes were evaluated.

Methods: Patient and donor organ selection were performed in the standard fashion.

Performance status at the time of lung retransplant predicts long-term function.

Background: Lung retransplantation is offered to select patients with chronic allograft dysfunction. Given the increased risk of morbidity and mortality conferred by retransplantation, post-transplant function should be considered in the decision of who and when to list. The aim of this study is to identify predictors of post-operative disability in patients undergoing lung retransplantation.

Outcomes following minimally invasive approaches . open extended lobectomy for non-small cell lung cancer: a propensity-matched analysis of the National Cancer Database.

Background: Traditional thoracotomy, an invasive surgical procedure, has been the standard approach for extended lobectomy in treating non-small cell lung cancer (NSCLC). However, minimally invasive surgery (MIS) has gained traction with advancements in surgical techniques. Despite this, the outcomes of extended lobectomy via a minimally invasive approach remain largely uncharted.

Lung transplantation in HIV seropositive recipients: An analysis of the UNOS registry.

Background: Experience with lung transplantation (LT) in patients with human immunodeficiency virus (HIV) is limited. Many studies have demonstrated the success of kidney and liver transplantation in HIV-seropositive (HIV+) patients. Our objective was to conduct a national registry analysis comparing LT outcomes in HIV+ to HIV-seronegative (HIV-) recipients.

Immediate Postoperative COVID-19 Infection after Lung Transplantation: A Systematic Review and Case Series.

Background: With new variants challenging the effectiveness of preventive measures, we are beginning to recognize the reality that COVID-19 will continue to pose an endemic threat. The manifestations of COVID-19 in lung transplant recipients during index admission are poorly understood with very few cases reported in recent lung transplant recipients. Optimal management of immunosuppression and antiviral therapy in recent transplant recipients is challenging.

A novel scoring system to predict survival in cirrhotic patients undergoing isolated lung transplantation: The PENS-CEPT score.

Cirrhosis is usually regarded as a contraindication to isolated lung transplantation (ILT). We sought to determine which patients with cirrhosis could safely undergo ILT. Based on a retrospective analysis of patients with cirrhosis who underwent ILT at our center between 2007 and 2020, we developed an exclusionary algorithm (PENS-CEPT: Pittsburgh ExclusioN Score in Cirrhotics Evaluated for Pulmonary Transplant) to help determine which patients can undergo ILT with minimal incurred risk from their underlying liver disease.

Impact of gastro-jejunostomy tube in lung transplant patients: a propensity-matched analysis.

Objectives: During the postoperative phase of lung transplantation, the surgical creation of a gastro-jejunostomy (GJ) may be deemed necessary for patients with severe oesophageal dysmotility, prolonged oral intake difficulties stemming from use of a ventilator or marked malnutrition. We explored the effects of postoperative GJ tube on survival and bronchiolitis obliterans syndrome in lung transplant recipients.

Methods: We retrospectively reviewed all lung transplants performed at our institution between 2011 and 2022.

Pneumatocele after lung transplantation.

Pneumatoceles are a known complication of pneumonia or trauma, especially in young children. A 44-year-old male with pulmonary veno-occlusive disease and pulmonary hypertension underwent double lung transplantation with cardiopulmonary support. The patient had experienced severe primary graft dysfunction and bilateral lower lobe pneumonia.

Waitlist Mortality and Extracorporeal Membrane Oxygenation Bridge to Lung Transplant.

Background: Use of extracorporeal membrane oxygenation (ECMO) as bridge to lung transplant has increased. However, little is known about patients placed on ECMO who die while on the waiting list. Using a national lung transplant data set, we investigated variables associated with waitlist mortality of patients bridged to lung transplant.