Postero-lateral elbow dislocation with traumatic brachial artery disruption.

Dislocations of the elbow are the second most common large joint dislocation, following shoulder dislocations. Most are closed reductions, especially posterior or posterolateral types, and do not require surgical intervention. When an elbow dislocation involves a vascular structure-usually the brachial artery-this injury becomes a rare and life-threatening emergency.

From Barriers to Tactics: Development Study of Behavioral Science-Informed Agentic Workflow for Personalized Nutrition Coaching.

Background: Effective management of cardiometabolic conditions requires sustained positive nutrition habits, often hindered by complex and individualized barriers. Direct human management is simply not scalable, while deterministic automated approaches to nutrition coaching may lack the personalization needed to address these diverse challenges.

Objective: We report the development and validation of a novel large language model (LLM)-powered agentic workflow designed to provide personalized nutrition coaching by directly identifying and mitigating patient-specific barriers.

Revisiting Scattering Enhancement from the Aharonov-Bohm Effect.

We revisit the problem of a charged particle scattering off of an Aharonov-Bohm cosmic string. A classic computation gave an infinite total scattering cross section, leading to a Callan-Rubakov-like enhancement which can have important implications on baryon number asymmetry in the early Universe. However, unlike the Callan-Rubakov effect, the Aharonov-Bohm interaction is topological and thus it is surprising that it leads to such a dramatic dynamical effect for single particle scattering.

Molecular subtyping of endometrial carcinoma cell lines uncovers subtype-specific targetable vulnerabilities.

Endometrial carcinoma (EC), the most common gynecologic cancer type in developed countries, encompasses four molecular subtypes (POLEmut, MMRd, p53abn, and NSMP) that have prognostic values and guide treatment decisions. Additionally, dual loss of ARID1A and ARID1B (referred to as ARID1A/B) characterizes a significant portion of dedifferentiated/undifferentiated EC (DD/UDEC), a rare but highly aggressive subtype of EC. To advance the translational research for ECs, we analyzed the genomic features of a panel of 39 EC cell lines, leading to the identification of cell lines representing each of these EC molecular subtype.

Beyond Thrombosis: Pulmonary Hypertension and Heart Failure in Patients With Myeloproliferative Neoplasms: JACC: CardioOncology State-of-the-Art Review.

Patients with myeloproliferative neoplasms (MPNs) are at increased risk for cardiovascular disease. Although thrombosis is a well-recognized complication, emerging evidence indicates that nonthrombotic conditions, including heart failure (HF) and pulmonary hypertension (PH), are also prevalent and associated with adverse cardiovascular and hematologic outcomes. Clinical and preclinical data suggest a shared pathophysiology linking MPNs to the development and progression of cardiomyopathy, HF, and both precapillary and postcapillary PH.

Rac1 in nephron progenitor cells is essential for kidney development.

Renal hypoplasia is a common congenital condition characterized by abnormally small kidneys with a reduced number of nephrons. During embryonic development, nephron formation relies on repetitive interactions between nephron progenitor cells (NPCs) and surrounding epithelial and stromal tissue, a process tightly regulated by genetic factors. NPCs are crucial to kidney development due to their self-renewal and multipotent abilities.

Visualizing Data for Diabetes Management in Patient Portals.

Effectively managing diabetes requires active patient engagement in monitoring crucial health metrics, such as HbA1c and glucose levels. However, many existing patient portals present this information in complex and confusing formats, hindering understanding and communication. This study established a prototype for a user-centered dashboard for diabetes management, designed to enhance patient comprehension and interaction with their health data by utilizing principles of relational data display.

Unveiling Endoscopic Procedures in MAUDE: An ETL-LLM Method.

The increased dependence on patient safety studies using the MAUDE database underscores the critical need to define and standardize the methods for extracting and analyzing event reports. The lack of reproducible methods leads to an inconsistent understanding of reported events and diminishes their effectiveness in informing clinicians. Thus, an ETL pipeline combined with LLMs was proposed to standardize the identification and interpretation of the reports.

Label-Free Single-Molecule Immunoassay.

Single-molecule immunoassay is a reliable technique for the detection and quantification of low-abundance blood biomarkers, which are essential for early disease diagnosis and biomedical research. However, current single-molecule methods predominantly rely on endpoint detection and necessitate signal amplification via labeling, which brings a variety of unwanted effects, like matrix effect and autofluorescence interference. This study introduces a real-time mass imaging-based label-free single-molecule immunoassay (LFSMiA).

Outcomes of Out-of-Hospital Cardiac Arrest at Centers With and Without On-Site Coronary Angiography: A Nationwide Analysis.

Background: The American Heart Association has advocated for regionalized systems of care for out-of-hospital cardiac arrest (OHCA), emphasizing admission to specialized centers with onsite coronary angiography. However, national data evaluating outcomes of OHCA admission to such centers remain limited.

Methods: Using the 2021 National Inpatient Sample, we identified all direct OHCA hospitalizations across US facilities.

Baseline Cardiac Biomarker Levels as Predictors of Cancer Risk in the MESA Cohort.

Background: Assessing the association between baseline levels of cardiac biomarkers and future cancer risk is critical to understand the cross talk between cardiovascular disease and cancer.

Objectives: The authors aimed to determine the association between baseline levels of high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) with cancer risk in the prospective MESA (Multi-Ethnic Study of Atherosclerosis) cohort.

Methods: We analyzed data from 6,244 MESA participants free of self-reported cancer and cardiovascular disease at baseline.

Building Patient-Facing Technology: A REDCap-Based Approach.

This work describes the architecture design of a patient-facing technology (PFT) based on the Research Electronic Data Capture (REDCap) platform and other tools to support cancer patients in self-tracking and managing medication concerns and symptoms during transitions of care. The design is guided by the Chronic Care Model (CCM) and User-Centered Design (UCD) principles for a personalized application to inform, engage, and empower patients. We describe the evolutional details of four major versions, which represent milestones of our PFT, highlighting how specific objectives were achieved and the barriers encountered.

NCCN Guidelines® Insights: Survivorship, Version 2.2025.

The NCCN Guidelines for Survivorship include screening, evaluation, and treatment recommendations for common physical and psychosocial problems resulting from adult-onset cancer and its treatment and provide a framework for coordination of survivorship care. They also include recommendations to help cancer survivors enhance their wellness and maintain a healthy lifestyle. These NCCN Guidelines Insights summarize the panel's current recommendations and recent updates regarding physical activity, nutrition, and weight management for cancer survivors.

The AhR regulates IFN-induced immune checkpoints in lung cancer cells through HNRNPH1, an RNA-binding protein, and INCR1, a novel long non-coding RNA.

Although immune checkpoint inhibitors show great promise, not all patients respond, and many do not achieve durable responses. Consequently, further investigations into potentially targetable molecules that regulate immune checkpoints are warranted. Previous studies in several cancers demonstrated that interferons produced by tumor-infiltrating leukocytes regulate immunosuppressive PD-L1, PD-L2, and IDO1 through JAK/STAT signaling.

Enhancing Patient Medication Safety at Home: A Patient-Facing Technology Architecture Integrating REDCap, Visualization Dashboards, and an AI- Driven Chatbot.

This work demonstrates a novel architecture for a patient-facing technology (PFT) that supports patients with cancer in self-managing medication concerns and symptoms after care transitions back home. Patient-generated data are collected and stored using the framework of Research Electronic Data Capture (REDCap), which serves as a key component of the architecture. Individual patient and administrator dashboards are integrated with REDCap to visualize medication or symptom-related data and generate customized report summaries.

Enhancing Theory-Driven Design and Evaluation of Patient-Facing Technologies.

Patient-facing technologies (PFTs) are essential tools for patient-centered outcome research. The current designs of PFTs need solid theoretical support and face challenges with maintenance and sustainability. This paper identifies PFT features and theoretical frameworks that support patient engagement in cancer care.

Developing a Dashboard to Facilitate Exploration of MAUDE Studies.

The MAUDE database is increasingly used for research. However, the MAUDE publications are scattered in literature databases with fragmented topics, hindering researchers' exploration and identification. To address this issue and enhance the visibility of MAUDE topics in literature, we followed the Gestalt data visualization principles, utilizing the PubMed API and Google Looker Studio to extract, organize, and visualize literature pertinent to MAUDE.

Outcomes of patients with cancer with acute coronary syndrome-associated cardiogenic shock.

Background: Cardiogenic shock (CS) is a common complication of acute coronary syndrome (ACS) and is associated with significant morbidity and mortality. Revascularization has been shown to reduce mortality in ACS-CS. Patients with cancer are at high risk of ACS and CS.

The safety and efficacy of left atrial appendage closure devices in patients with non-traumatic intracranial hemorrhage.

Introduction: Anticoagulation in patients with atrial fibrillation and a history of intracranial hemorrhage (ICH) presents with challenges when balancing the risk of recurrent bleeding vs ischemic stroke. Left atrial appendage closure (LAAC) devices have shown promise as a minimally invasive method to prevent stroke without long-term anticoagulation. The goal of our study is to evaluate the efficacy of LAAC devices in patients with non-traumatic ICH and intraspinal hemorrhage which has not been well studied.

Hematology-oncology provider perspectives regarding lymphoma treatment and cardioprotective strategies in patients with lymphoma at high risk for heart failure.

The optimal treatment of patients with diffuse large B-cell lymphoma (DLBCL) or Hodgkin lymphoma (HL) with preexisting cardiomyopathy is uncertain. An anonymous, electronic survey was distributed by e-mail to three US lymphoma cooperative groups, two community hospitals, and twelve academic medical systems, and distributed at one international lymphoma meeting. Fifty hematology-oncology providers caring for patients with lymphoma were included.

Safety and efficacy of immune checkpoint therapy for the treatment of patients with cardiac metastasis: a multicenter international retrospective study.

Background: Data on the safety profiles and clinical outcomes of patients with solid tumors and cardiac metastasis treated with immune checkpoint inhibitors (ICIs) are limited.

Methods: This is an international multicenter retrospective study of patients with cancer and cardiac metastasis at baseline. Patients who had received ≥1 dose of ICI were included.

Outcomes of patients with cancer admitted with heart failure-associated cardiogenic shock.

Aims: Acute decompensated heart failure (HF) can progress to cardiogenic shock, and patients with cancer are at an increased risk of HF compared with patients without cancer. However, limited data exist on outcomes of patients admitted for HF-related cardiogenic shock (HF-CS) with cancer vs. without cancer.

Integration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology.

Purpose Of Review: Cardiovascular computed tomography (CCT) is a versatile, readily available, and non-invasive imaging tool with high-resolution capabilities in many cardiovascular diseases (CVD). Our review explains the increased risk of CVD among patients with cancer due to chemoradiotherapies, shared risk factors and cancer itself and explores the expanding role of CCT in the detection, surveillance, and management of numerous CVD among these patients.

Recent Findings: Recent research has highlighted the versatility and enhanced resolution capabilities of CCT in assessing a wide range of cardiovascular diseases.