Publications by authors named "Enas Alwohoush"
Extracellular vesicles (EVs), which include exosomes (Exos) and microvesicles (MVs), play a crucial role in intercellular communication and exert various biological activities by delivering specific cargoes of functional molecules, such as RNAs and proteins, to target cells. EVs secreted by human mesenchymal stem cells (hMSCs) have demonstrated their capacity to replace intact MSCs in tissue repair and regeneration. Induced mesenchymal stem cells (iMSCs) derived from induced pluripotent stem cells (iPSCs) present a promising alternative to traditional MSCs for producing EVs.
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- Mesenchymal stem cells (MSCs) often face high mortality rates after transplantation, making hypoxia pre-conditioning a vital technique to enhance their survival and functionality.
- Induced pluripotent stem cell-derived MSCs (iMSCs) are emerging as a promising alternative, and this study investigated how short-term severe hypoxia (1% O for 24 hours) affects their growth, viability, and differentiation.
- The results showed that while hypoxia negatively impacted iMSCs' proliferation and viability, it might have long-term benefits for their growth and differentiation, indicating a need for further research on the effects of prolonged hypoxia recovery.
For the past two decades, cellular senescence has been recognized as a central component of the tumor cell response to chemotherapy and radiation. Traditionally, this form of senescence, termed Therapy-Induced Senescence (TIS), was linked to extensive nuclear damage precipitated by classical genotoxic chemotherapy. However, a number of other forms of therapy have also been shown to induce senescence in tumor cells independently of direct genomic damage.
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